Hill T M, Sadler J R, Betz J L
J Virol. 1985 Oct;56(1):312-6. doi: 10.1128/JVI.56.1.312-316.1985.
Herpes simplex virus (HSV) strains HSV type 1 (HSV-1) KOS and HSV-2 186 are representative of delayed and early shutoff strains, respectively, with regard to their ability to inhibit protein synthesis in Friend erythroleukemia cells. When these cells were simultaneously infected with HSV-1 KOS and HSV-2 186, HSV-1 KOS interfered with the rapid suppression of globin synthesis induced by HSV-2 186. The observed interference was competitive and not due to exclusion of HSV-2 by HSV-1 at the level of adsorption. Furthermore, UV-irradiated HSV-1 KOS was also effective at interfering with the early shutoff function of HSV-2 186, indicating that a virion component is responsible for the observed interference.
就单纯疱疹病毒（HSV）1型（HSV - 1）KOS株和HSV - 2 186株抑制Friend红白血病细胞中蛋白质合成的能力而言，它们分别代表了延迟关闭和早期关闭株。当这些细胞同时感染HSV - 1 KOS和HSV - 2 186时，HSV - 1 KOS干扰了HSV - 2 186诱导的珠蛋白合成的快速抑制。观察到的干扰是竞争性的，并非由于HSV - 1在吸附水平上排斥HSV - 2。此外，紫外线照射的HSV - 1 KOS也能有效干扰HSV - 2 186的早期关闭功能，这表明一种病毒体成分是观察到的干扰的原因。
