Deschenes M R, Maresh C M, Armstrong L E, Covault J, Kraemer W J, Crivello J F
Department of Physiology and Neurobiology, University of Connecticut, Storrs 06269-3042.
J Steroid Biochem Mol Biol. 1994 Aug;50(3-4):175-9. doi: 10.1016/0960-0760(94)90026-4.
This study examined the effects of different exercise training programs on androgen receptor content and receptor affinity to dihydrotestosterone in fast glycolytic (FG) and slow oxidative (SO) skeletal muscle fibers in rats. Twenty-four male Sprague-Dawley rats were equally divided into three groups: control, endurance exercise trained and resistance exercise trained. After the exercise programs were completed, the extensor digitorum longus (EDL), predominantly a FG muscle, and the soleus, predominantly a SO muscle, were isolated, weighted and both androgen receptor content and affinity to dihydrotestosterone were determined. Resistance training evoked a significant (P < 0.05) hypertrophic response in the soleus but not the EDL. Endurance training was not associated with any significant hypertrophy in either the soleus or the EDL. Neither the endurance nor the resistance training program resulted in changes in androgen receptor affinity to dihydrotestosterone. However, alterations in androgen receptor content were noted. The endurance training program resulted in a significant increase in androgen receptor content in the soleus, but no significant difference in the EDL. The resistance training program elicited a significant decrease in androgen receptor content in the soleus, and a significant increase in the EDL. These results indicate that different exercise stimuli induce changes in androgen receptor content that are specific to skeletal muscle fiber type.
本研究检测了不同运动训练方案对大鼠快糖酵解（FG）和慢氧化（SO）骨骼肌纤维中雄激素受体含量以及受体与双氢睾酮亲和力的影响。将24只雄性斯普拉格-道利大鼠平均分为三组：对照组、耐力运动训练组和抗阻运动训练组。运动方案完成后，分离出主要为FG肌的趾长伸肌（EDL）和主要为SO肌的比目鱼肌，称重并测定雄激素受体含量以及与双氢睾酮的亲和力。抗阻训练在比目鱼肌中引发了显著（P < 0.05）的肥大反应，但在EDL中未引发。耐力训练在比目鱼肌或EDL中均未引发任何显著的肥大。耐力训练方案和抗阻训练方案均未导致雄激素受体与双氢睾酮的亲和力发生变化。然而，观察到了雄激素受体含量的改变。耐力训练方案导致比目鱼肌中雄激素受体含量显著增加，但在EDL中无显著差异。抗阻训练方案使比目鱼肌中雄激素受体含量显著降低，而使EDL中雄激素受体含量显著增加。这些结果表明，不同的运动刺激会诱导雄激素受体含量发生变化，且这种变化对骨骼肌纤维类型具有特异性。
