[抗结核化学预防：肝毒性与治疗依从性]

[Antitubercular chemoprevention: hepatotoxicity and therapeutic compliance].

作者信息

Hortoneda Giménez M, Alfonso Sánchez J L, Cortés Vizcaíno C, Sabater Pons A

机构信息

Area de Medicina Preventiva y Salud Pública, Facultad de Medicina, Hospital La Fe, Valencía.

出版信息

An Med Interna. 1993 Dec;10(12):587-9.

PMID:8049323

Abstract

We studied 142 patients who received antituberculous chemoprophylaxis with isoniacide. We evaluated the increase in GOT and PGT levels, observing higher than normal values in 10.56% and 21.83% of the cases, respectively. This increase was near the limit of the statistical significance with respect to sex and it was not related with previous episodes of hepatotoxicity, although it was related to age, with a lower number of hepatic disorders among the younger groups. The presence of hepatotoxicity forced us to discontinue the therapy in just 2.81% of the cases. The level of therapy compliance was 69.1% for women and 85.25% for men, being greatest in the age group below 13 years (86.89%).

摘要

我们研究了142例接受异烟肼抗结核化学预防的患者。我们评估了谷草转氨酶（GOT）和谷丙转氨酶（PGT）水平的升高情况，分别观察到10.56%和21.83%的病例高于正常值。这种升高在性别方面接近统计学意义的极限，并且与既往肝毒性发作无关，尽管它与年龄有关，较年轻组的肝脏疾病数量较少。肝毒性的存在仅在2.81%的病例中迫使我们停止治疗。女性的治疗依从率为69.1%，男性为85.25%，在13岁以下年龄组中最高（86.89%）。