Wheeler G, Cumming D, Burnham R, Maclean I, Sloley B D, Bhambhani Y, Steadward R D
Rick Hansen Centre, University of Alberta Hospital, Edmonton, Canada.
Paraplegia. 1994 May;32(5):292-9. doi: 10.1038/sc.1994.51.
Episodes of short high intensity exercise are associated with an increase in circulating total testosterone (T) in men. Mechanisms may include hemoconcentration, decreased metabolic clearance and/or increased synthesis. Beta-blockade abolishes the T response suggesting a direct beta-adrenergic effect on the testes. Some spinal cord injured (SCI) athletes deliberately induce autonomic dysreflexia (boosting) to enhance performance. Associated with this practice are elevated catecholamine (CA) levels and exaggerated responses to serum catecholamine levels. Since basal T levels are reported to be normal in the SCI male, the T response to acute high intensity exercise might be expected to be exaggerated by boosting and associated elevated CA levels. The acute exercise T response has not been examined in SCI men to date. To determine whether the increased CA values associated with boosting enhanced the exercise-induced T elevation we measured circulating levels of T, cortisol (C), norepinephrine (NE) and epinephrine (E) before and after maximal exertion and a simulated 7.5 km race with and without boosting in eight elite quadriplegic athletes. Maximal incremental exercise and a simulated 7.5 km race resulted in a rise in T similar to able bodied men under normal exercise conditions. Under boosted conditions the rise in T was eliminated while NE levels were significantly elevated above unboosted levels. The data may suggest an inhibitory role for CA on T production or release under conditions of extreme stress. Other possible mechanisms include C induced suppression, impaired gonadotropin stimulation of the Leydig cell and CA mediated alterations in gonadal blood supply.
短时间高强度运动发作与男性循环总睾酮（T）水平升高有关。其机制可能包括血液浓缩、代谢清除率降低和/或合成增加。β受体阻滞剂可消除睾酮反应，提示对睾丸有直接的β肾上腺素能作用。一些脊髓损伤（SCI）运动员故意诱发自主神经反射异常（升压）以提高成绩。这种做法伴随着儿茶酚胺（CA）水平升高以及对血清儿茶酚胺水平的过度反应。由于据报道SCI男性的基础睾酮水平正常，因此急性高强度运动后的睾酮反应可能会因升压和相关的CA水平升高而被夸大。迄今为止，尚未对SCI男性的急性运动睾酮反应进行研究。为了确定与升压相关的CA值升高是否会增强运动诱导的睾酮升高，我们在八名精英四肢瘫痪运动员进行最大运动量运动以及模拟7.5公里比赛前后，分别在有升压和无升压的情况下测量了循环中的睾酮（T）、皮质醇（C）、去甲肾上腺素（NE）和肾上腺素（E）水平。最大递增运动和模拟7.5公里比赛导致睾酮升高，这与正常运动条件下的健全男性相似。在升压条件下，睾酮升高被消除，而去甲肾上腺素水平显著高于未升压水平。这些数据可能表明在极端应激条件下，儿茶酚胺对睾酮产生或释放具有抑制作用。其他可能的机制包括皮质醇诱导的抑制、促性腺激素对睾丸间质细胞刺激受损以及儿茶酚胺介导的性腺血液供应改变。
