Wheeler G D, Ashley E A, Harber V, Laskin J J, Olenik L M, Sloley D, Burnham R, Steadward R D, Cumming D C
Rick Hansen Centre, University of Alberta, Edmonton, Canada.
Spinal Cord. 1996 May;34(5):264-7. doi: 10.1038/sc.1996.47.
Functional electrical stimulation (FES) assisted resistance training has been effective in increasing muscular strength and endurance in spinal cord injured men and women in preparation for FES-assisted cycle programs and for FES-assisted standing and walking. Increases in blood pressure and a concomitant bradycardia suggestive of autonomic dysreflexia have been reported during FES-assisted resistance training. Self-induced autonomic dysreflexia in athletes who use wheelchairs suppressed the normal exercise induced serum testosterone increase. We, therefore, examined the changes in hematocrit and circulating levels of testosterone, sex hormone binding globulin (SHBG), cortisol, prolactin, norepinephrine and epinephrine during FES assisted resistance exercise in five high spinal cord injured men (SCI) and comparable maximal exercise in five able bodied controls (AB). Mean serum testosterone levels significantly increased with FES-assisted resistance training in SCI and maximal resistance exercise in AB with no significant change in hematocrit or SHBG. Prolactin, cortisol and epinephrine levels were unchanged while norepinephrine levels were significantly increased in SCI and AB. These findings suggest that there is no concern over inadequate physiological androgen response to an exercise stimulus in SCI. The data do not support the previous findings that elevated levels of norepinephrine in autonomic dysreflexia suppress testosterone response to exercise.
功能性电刺激（FES）辅助抗阻训练在增强脊髓损伤男性和女性的肌肉力量和耐力方面已被证明是有效的，这有助于他们为FES辅助的骑行项目以及FES辅助的站立和行走做准备。据报道，在FES辅助抗阻训练期间，会出现血压升高以及伴随的心动过缓，这提示可能存在自主神经反射异常。使用轮椅的运动员出现的自主诱发的自主神经反射异常抑制了正常运动诱导的血清睾酮升高。因此，我们研究了5名高位脊髓损伤男性（SCI）在FES辅助抗阻运动期间以及5名健全对照者（AB）进行同等强度最大运动期间，血细胞比容以及睾酮、性激素结合球蛋白（SHBG）、皮质醇、催乳素、去甲肾上腺素和肾上腺素循环水平的变化。SCI组在FES辅助抗阻训练以及AB组在最大抗阻运动期间，血清睾酮平均水平显著升高，而血细胞比容或SHBG无显著变化。催乳素、皮质醇和肾上腺素水平未改变，而SCI组和AB组的去甲肾上腺素水平显著升高。这些发现表明，无需担心SCI患者对运动刺激的生理性雄激素反应不足。这些数据不支持先前的研究结果，即自主神经反射异常时去甲肾上腺素水平升高会抑制睾酮对运动的反应。
