Franch A, Castellote C, Castell M
Experimental Immunopathology Research Group, Faculty of Pharmacy, University of Barcelona, Spain.
Pathol Res Pract. 1994 Feb;190(2):155-8. doi: 10.1016/S0344-0338(11)80706-5.
The aim of this study was to elucidate the existence of autoantibodies directed to type I collagen as a response to connective tissue alterations that occur in inflammatory diseases. We have demonstrated the presence of antibodies to type I collagen during the time course of adjuvant arthritis, by means of the ELISA technique. These autoantibodies reached the highest levels in advanced phases of the arthritic process from 8 to 10 weeks after mycobacteria administration. The hind-paw swelling and the anti-type I collagen antibodies remained for at least 18 weeks post-induction.
本研究的目的是阐明针对I型胶原蛋白的自身抗体的存在，作为对炎症性疾病中发生的结缔组织改变的一种反应。我们通过ELISA技术证明了在佐剂性关节炎病程中存在抗I型胶原蛋白抗体。这些自身抗体在给予分枝杆菌后8至10周的关节炎进程晚期达到最高水平。后爪肿胀和抗I型胶原蛋白抗体在诱导后至少持续18周。
