咖啡因对吸入二氧化碳通气反应的影响。
Effect of caffeine on the ventilatory response to inhaled carbon dioxide.
作者信息
Pianosi P, Grondin D, Desmond K, Coates A L, Aranda J V
机构信息
Respiratory Medicine Service, McGill University-Montreal Children's Hospital Research Institute, Quebec, Canada.
出版信息
Respir Physiol. 1994 Mar;95(3):311-20. doi: 10.1016/0034-5687(94)90093-0.
We investigated the effect of caffeine on the hypercapnic ventilatory response (HCVR) using steady state (SS) and rebreathing (RB) methods in 6 subjects. They received caffeine (5 mg/kg) or saline intravenously in a randomized, double-blind, crossover manner, with measurement of serum caffeine levels. PETCO2 and (VE), normalized for vital capacity (VC), were measured continually during RB and during the last 5 min of SS runs. The slope of the VE-PETCO2 response increased from 0.21 +/- 0.14 to 0.38 +/- 0.14 and from 0.23 +/- 0.12 to 0.59 +/- 0.45 VC.min-1.mmHg-1, measured by RB and SS respectively (P < 0.05). Plotting VT vs PETCO2 revealed a parallel shift (additive effect) in the response measured by RB after caffeine; but an increased slope (multiplicative effect) in the VT-PETCO2 relation measured in SS. We conclude that caffeine acts as a respiratory stimulant and increases the HCVR, but that assessment of the caffeine-CO2 interaction is dependent on the methodology employed.
我们采用稳态（SS）和重复呼吸（RB）方法，在6名受试者中研究了咖啡因对高碳酸通气反应（HCVR）的影响。他们以随机、双盲、交叉的方式静脉注射咖啡因（5 mg/kg）或生理盐水，并检测血清咖啡因水平。在重复呼吸期间以及稳态实验的最后5分钟内，持续测量经肺活量（VC）标准化的呼气末二氧化碳分压（PETCO2）和每分钟通气量（VE）。分别通过重复呼吸法和稳态法测得的每分钟通气量-呼气末二氧化碳分压反应斜率，从0.21±0.14增加到0.38±0.14，以及从0.23±0.12增加到0.59±0.45 升/分钟·毫米汞柱-1（P<0.05）。绘制潮气量（VT）与呼气末二氧化碳分压的关系图显示，咖啡因作用后，重复呼吸法测得的反应呈平行移位（相加效应）；但稳态法测得的潮气量-呼气末二氧化碳分压关系斜率增加（相乘效应）。我们得出结论，咖啡因作为一种呼吸兴奋剂可增强高碳酸通气反应，但咖啡因与二氧化碳相互作用的评估取决于所采用的方法。
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