Twigg H L, Soliman D M, Spain B A
Department of Medicine, Indiana University Medical Center, Indianapolis 46202.
AIDS. 1994 May;8(5):611-8. doi: 10.1097/00002030-199405000-00006.
To determine the effects of smoking on alveolar macrophage (AM) accessory cell (AC) function and the incidence of lymphocytic alveolitis in asymptomatic HIV-infected individuals.
AM AC function in smoking and nonsmoking HIV-positive volunteers was measured in concanavalin A and pokeweed mitogen assays. Mitogen-induced AM-T-cell adherence was determined. AM cytokine secretion was analyzed by interleukin (IL)-6 bioassay and IL-1 enzyme-linked immunosorbent assay (ELISA). The incidence of lymphocytic alveolitis in both groups was determined.
AM from smokers were significantly poorer AC than AM from nonsmokers. Though AM-T-cell adherence was unaffected by smoking, IL-1 and IL-6 secretion was significantly impaired. Lymphocytic alveolitis was significantly less common in HIV-infected smokers.
Smoking reduces AM AC function in HIV-infected individuals, probably by impairing secretion of cytokines important in T-cell proliferation. This may explain the decreased incidence of lymphocytic alveolitis in HIV-infected people who smoke.
