van der Schaft T L, Mooy C M, de Bruijn W C, Mulder P G, Pameyer J H, de Jong P T
Institute of Ophthalmology, Erasmus University Rotterdam, The Netherlands.
Br J Ophthalmol. 1994 Jun;78(6):441-5. doi: 10.1136/bjo.78.6.441.
After cataract extraction with implantation of an intraocular lens the increased transmission of ultraviolet and blue light may accelerate the development of age-related macular degeneration by producing free radicals in the retina. The maculae of 82 randomly selected postmortem human pseudophakic eyes and 16 fellow phakic eyes were examined by light microscopy. The presence of a basal laminar deposit, hard and soft drusen, thickening and calcification of Bruch's membrane, geographic atrophy, subretinal neovascularisation, and disciform scars was assessed in a standardised way. An age-matched series of 126 postmortem phakic eyes was used as control group. There was no difference between the two groups, except for a higher prevalence of hard drusen (exact trend test, p = 0.038) and disciform scars for the pseudophakic eyes (Fisher's exact test, p = 0.007). There was no significant correlation between either age-related changes in the macula or disciform degeneration and the length of time between cataract surgery and death. No significant difference was found between pseudophakic eyes with or without ultraviolet filter. These findings do not confirm that disciform scar formation is caused by an increase in ultraviolet or blue light.
在白内障摘除并植入人工晶状体后，紫外线和蓝光透射率的增加可能通过在视网膜中产生自由基而加速年龄相关性黄斑变性的发展。对82只随机选取的死后人类假晶状体眼和16只对侧晶状体眼的黄斑进行了光学显微镜检查。以标准化方式评估了基底膜沉积物、硬性和软性玻璃膜疣、布鲁赫膜增厚和钙化、地图样萎缩、视网膜下新生血管形成以及盘状瘢痕的存在情况。将126只年龄匹配的死后晶状体眼作为对照组。两组之间除了硬性玻璃膜疣的患病率较高（确切趋势检验，p = 0.038）以及假晶状体眼的盘状瘢痕患病率较高（费舍尔精确检验，p = 0.007）外，没有差异。黄斑的年龄相关性变化或盘状变性与白内障手术和死亡之间的时间长度均无显著相关性。有或没有紫外线滤光片的假晶状体眼之间未发现显著差异。这些发现并未证实盘状瘢痕形成是由紫外线或蓝光增加所致。
