Moodaley L, Liu C, Woodward E G, O'Brart D, Muir M K, Buckley R
Contact Lens and Prosthesis Department, Moorfields Eye Hospital, London.
Br J Ophthalmol. 1994 Jun;78(6):454-7. doi: 10.1136/bjo.78.6.454.
Contact lens intolerance in keratoconus may be due to the formation of a proud nebula at or near the apex of the cone. Excimer laser superficial keratectomy was performed as an outpatients with proud nebulae as treatment patients with proud nebulae as treatment for their contact lens intolerance. The mean period of contact lens wear before the development of intolerance was 13.4 years (range 2 to 27 years). Following the development of intolerance, three patients abandoned contact lens wear in the affected eye while the remainder experienced a reduction in comfortable wearing time (mean = 3.75 hours; range: 0-14 hours). All patients had good potential Snellen visual acuity with a contact lens of 6/9 (nine eyes) and 6/12 (one eye). The proud nebulae were directly ablated with a 193 nm ArF excimer laser using a 1 mm diameter beam. Between 100-150 pulses were sufficient to ablate the raised area. Patients experienced no pain during the procedure and reported minimal discomfort postoperatively. In all cases flattening of the proud nebulae was achieved. Seven patients were able to resume regular contact lens wear (mean wearing time = 10.17 hours; range 8 to 16 hours). In three patients, resumption of contact lens wear was unsuccessful because of cone steepness. All patients achieved postoperative Snellen visual acuity of 6/12 or better with a contact lens. Four patients experienced a loss of one line in Snellen acuity. The mean follow up period was 8.3 months (range 2 to 17 months). Excimer laser superficial keratectomy is a useful technique for the treatment of contact lens intolerance caused by proud nebulae in patients with keratoconus. Penetrating keratoplasty is thus avoided.
圆锥角膜患者的隐形眼镜不耐受可能是由于在圆锥顶点或其附近形成了一个突出的角膜云翳。对于因突出角膜云翳导致隐形眼镜不耐受的患者,门诊进行了准分子激光表层角膜切除术。在出现不耐受之前,隐形眼镜佩戴的平均时长为13.4年(范围为2至27年)。出现不耐受后,3例患者患眼放弃佩戴隐形眼镜,其余患者舒适佩戴时间减少(平均为3.75小时;范围为0至14小时)。所有患者佩戴隐形眼镜时的最佳矫正视力均良好,其中9眼为6/9,1眼为6/12。使用直径1mm的光束,用193nm的ArF准分子激光直接消融突出的角膜云翳。100至150个脉冲足以消融隆起区域。手术过程中患者无疼痛,术后不适也很轻微。所有病例中突出的角膜云翳均变平。7例患者能够恢复规律佩戴隐形眼镜(平均佩戴时间为10.17小时;范围为8至16小时)。3例患者因圆锥陡峭,恢复佩戴隐形眼镜未成功。所有患者佩戴隐形眼镜术后的最佳矫正视力均达到6/12或更好。4例患者的最佳矫正视力下降了一行。平均随访期为8.3个月(范围为2至17个月)。准分子激光表层角膜切除术是治疗圆锥角膜患者因突出角膜云翳导致隐形眼镜不耐受的一种有效技术,从而避免了穿透性角膜移植术。