F344雄性大鼠中MeIQx致癌性的剂量反应研究。

Dose-response study of MeIQx carcinogenicity in F344 male rats.

作者信息

Kushida H, Wakabayashi K, Sato H, Katami M, Kurosaka R, Nagao M

机构信息

Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan.

出版信息

Cancer Lett. 1994 Aug 15;83(1-2):31-5. doi: 10.1016/0304-3835(94)90295-x.

DOI:10.1016/0304-3835(94)90295-x

PMID:8062230

Abstract

The dose-dependence of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) carcinogenicity when given in the diet continuously throughout the experiment (56 weeks) at doses of 100, 200 and 400 ppm, was examined in F344 male rats. Tumors developed dose-dependently in the liver, Zymbal glands and skin in the experimental groups, but were lacking in the control group. Benign tumors such as adenomas and papillomas were found in rats given 100 ppm MeIQx, whereas carcinomas were induced by 200 and 400 ppm MeIQx treatments. The incidences of hepatocellular carcinomas in the 100, 200 and 400 ppm MeIQx groups were 0, 45 and 94%, and of Zymbal gland squamous cell carcinomas were 0, 10 and 56%, respectively. Thus, the response in terms of carcinoma development in these organs in relation to dose of MeIQx seemed to be non-linear.

摘要

在整个实验（56周）期间，以100、200和400 ppm的剂量持续添加到饲料中，对F344雄性大鼠进行2-氨基-3,8-二甲基咪唑并[4,5-f]喹喔啉（MeIQx）致癌性的剂量依赖性研究。在实验组中，肝脏、鼓室腺和皮肤中的肿瘤呈剂量依赖性发展，但对照组未出现肿瘤。在给予100 ppm MeIQx的大鼠中发现了腺瘤和乳头状瘤等良性肿瘤，而200和400 ppm MeIQx处理诱导产生了癌。100、200和400 ppm MeIQx组肝细胞癌的发生率分别为0%、45%和94%，鼓室腺鳞状细胞癌的发生率分别为0%、10%和56%。因此，这些器官中与MeIQx剂量相关的癌发生反应似乎是非线性的。