Ferreiro J A
Division of Surgical Pathology, Mayo Clinic, Rochester, MN 55905.
Histopathology. 1994 Jun;24(6):539-42. doi: 10.1111/j.1365-2559.1994.tb00572.x.
An immunohistochemical study of basal cell adenoma of the major salivary glands was performed. All basal cell adenomas showed similar staining patterns. Carcinoembryonic antigen was expressed in the apical portions of luminal cells, in the luminal secretions, and in the duct-lining cells. Epithelial membrane antigen showed a similar pattern of expression but was less frequently present in duct-lining cells. Keratin expression was found in all epithelial cells but not in stromal cells. S-100 protein was strongly expressed in stromal cells, with focal positivity of cells in epithelial nests. Vimentin expression was noted in stromal cells and the outer layer of epithelial nests. Staining for muscle-specific actin was negative in both stromal cells and epithelial nests. Thus, there appears to be evidence of myoepithelial cell participation in the histogenesis of basal cell adenomas, and at least some basal cell adenomas appear to be closely related to pleomorphic adenomas.
对大唾液腺基底细胞腺瘤进行了免疫组织化学研究。所有基底细胞腺瘤均表现出相似的染色模式。癌胚抗原在管腔细胞的顶端部分、管腔分泌物及导管内衬细胞中表达。上皮膜抗原呈现类似的表达模式，但在导管内衬细胞中出现频率较低。角蛋白在所有上皮细胞中表达，但在间质细胞中不表达。S-100蛋白在间质细胞中强烈表达，上皮巢中的细胞有局灶性阳性。波形蛋白在间质细胞和上皮巢外层有表达。肌肉特异性肌动蛋白在间质细胞和上皮巢中的染色均为阴性。因此，似乎有证据表明肌上皮细胞参与了基底细胞腺瘤的组织发生，并且至少一些基底细胞腺瘤似乎与多形性腺瘤密切相关。
