一种致病真菌中超氧化物歧化酶与黑色素之间的关系
Relationship between superoxide dismutase and melanin in a pathogenic fungus.
作者信息
Jacobson E S, Jenkins N D, Todd J M
机构信息
Research Service, McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249.
出版信息
Infect Immun. 1994 Sep;62(9):4085-6. doi: 10.1128/iai.62.9.4085-4086.1994.
Abstract
Since melanin is considered a virulence factor in Cryptococcus neoformans, its suppression at 37 degrees C has been perplexing. We now show an opposite thermal regulation of superoxide dismutase (SOD), consistent with a compensatory mechanism. Moreover, we demonstrate normal SOD and catalase levels in albino, oxygen-sensitive mutants. These results suggest that melanin is an antioxidant factor comparable in importance to SOD.
摘要
由于黑色素被认为是新型隐球菌的一种致病因子，其在37摄氏度时受到抑制一直令人困惑。我们现在展示了超氧化物歧化酶（SOD）相反的热调节，这与一种补偿机制一致。此外，我们证明了白化病、对氧敏感的突变体中SOD和过氧化氢酶水平正常。这些结果表明，黑色素是一种抗氧化因子，其重要性与SOD相当。
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