Whitaker S B, Bouquot J E
Department of Oral Diagnosis, School of Dentistry, Medical College of Georgia, Augusta.
Oral Surg Oral Med Oral Pathol. 1994 Jun;77(6):641-4. doi: 10.1016/0030-4220(94)90327-1.
It is well known that the central giant cell lesion (granuloma) of the jaws has a distinct female predilection. In addition, occasional cases of central giant cell lesion have been reported to have undergone marked proliferation in pregnant patients and in those undergoing hormonal therapy. As such, we have evaluated 10 central giant cell lesions for the detection of estrogen and progesterone receptor proteins with the use of immunoperoxidase staining. Surprisingly, however, immunostaining for estrogen receptor protein was essentially negative in all cases examined. Although an occasional mononuclear cell stained weakly positive for estrogen receptor protein, these findings suggest that in most cases, factors other than a direct influence of the ovarian hormones, estrogen and progesterone, are responsible for the development and growth of these lesions.
众所周知，颌骨中央巨细胞病变（肉芽肿）明显好发于女性。此外，有报道称，少数中央巨细胞病变病例在孕妇和接受激素治疗的患者中出现了显著增生。因此，我们利用免疫过氧化物酶染色对10例中央巨细胞病变进行了雌激素和孕激素受体蛋白检测。然而，令人惊讶的是，在所检查的所有病例中，雌激素受体蛋白的免疫染色基本为阴性。尽管偶尔有单个核细胞对雌激素受体蛋白呈弱阳性染色，但这些结果表明，在大多数情况下，这些病变的发生和发展是由卵巢激素雌激素和孕激素的直接影响以外的因素引起的。
