利福平用于兔实验性肺炎球菌性脑膜炎的治疗。
Rifampin for therapy of experimental pneumococcal meningitis in rabbits.
作者信息
Nau R, Kaye K, Sachdeva M, Sande E R, Täuber M G
机构信息
Infectious Diseases Laboratory, San Francisco General Hospital, California 94110.
出版信息
Antimicrob Agents Chemother. 1994 May;38(5):1186-9. doi: 10.1128/AAC.38.5.1186.
Abstract
Rifampin at a maximally effective dose was less active than ceftriaxone (both drugs at 10 mg/kg of body weight.h) in a rabbit model of pneumococcal meningitis (delta log10 CFU/ml.h, -0.40 +/- 0.13 versus -0.77 +/- 0.18; P < 0.01). The bactericidal activity of rifampin decreased at concentrations in cerebrospinal fluid greater than those that are clinically achievable, and use of rifampin in combination with ofloxacin had no synergistic or additive effect.
摘要
在肺炎球菌性脑膜炎兔模型中，最大有效剂量的利福平活性低于头孢曲松（两种药物均为10mg/kg体重·小时）（对数10CFU/ml·小时的变化量，-0.40±0.13对-0.77±0.18；P<0.01）。当脑脊液中的利福平浓度高于临床可达到的浓度时，其杀菌活性降低，并且利福平与氧氟沙星联合使用没有协同或相加作用。
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