免疫抑制性麻疹脑炎

Immunosuppressive measles encephalitis.

作者信息

Chen R E, Ramsay D A, deVeber L L, Assis L J, Levin S D

机构信息

Department of Clinical Neurological Sciences, Victoria Hospital, London, Ontario, Canada.

出版信息

Pediatr Neurol. 1994 Jun;10(4):325-7. doi: 10.1016/0887-8994(94)90131-7.

DOI:10.1016/0887-8994(94)90131-7

PMID:8068161

Abstract

A case of immunosuppressive measles (rubeola) encephalitis in a 12-year-old boy in remission from acute lymphoblastic leukemia is described. The patient presented with focal seizures which led to epilepsia partialis continua and then progressive obtundation. Magnetic resonance imaging revealed focal abnormalities, predominantly in the cortex, that on light and electron microscopic examination were demonstrated to be highly localized areas of neuronal loss, gliosis, and secondary Wallerian degeneration with paramyxovirus inclusions in the oligodendrocytes and surviving neurons.

摘要

本文描述了一名12岁急性淋巴细胞白血病缓解期男孩发生免疫抑制性麻疹（风疹）脑炎的病例。该患者出现局灶性癫痫发作，进而发展为持续性部分性癫痫，随后逐渐昏迷。磁共振成像显示局灶性异常，主要位于皮质，光镜和电镜检查显示为高度局限性的神经元丢失、胶质细胞增生以及继发性华勒变性区域，少突胶质细胞和存活神经元中有副粘病毒包涵体。