Naides S J
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242.
Curr Opin Rheumatol. 1994 Jul;6(4):423-8. doi: 10.1097/00002281-199407000-00012.
Viruses have long been considered candidates for infectious etiologic agents or cofactors in the development of rheumatic diseases. The current epidemic of HIV infection and the recognition of "emerging viruses" has focused interest on the possible role of viruses in pathogenesis of diseases without defined etiology. Over the past year, the role of parvovirus B19 in chronic arthropathy was further defined. Additional data added to our understanding of the mechanisms by which rubella virus may cause chronic arthritis. We were reminded of the potential the togaviruses have to cause epidemics of febrile arthritis. The developing story of hepatitis C virus in essential mixed cryoglobulinemia encourages us to explore strategies for specific antiviral therapies. The members of the herpesvirus family came under scrutiny for their role in Sjögren's syndrome. The retroviruses continue to attract attention because of rheumatic disease syndromes in AIDS patients and the suggestion that still undefined retroviruses may play an etiologic role in rheumatoid arthritis. This review highlights efforts made in the past year to elucidate the role of viral infection in rheumatologic disease.
长期以来，病毒一直被视为风湿性疾病发展过程中感染性病因或辅助因素的候选者。当前的艾滋病毒感染流行以及对“新兴病毒”的认识，使人们将兴趣集中在病毒在病因不明疾病发病机制中的可能作用上。在过去的一年里，细小病毒B19在慢性关节病中的作用得到了进一步明确。更多数据增进了我们对风疹病毒可能导致慢性关节炎机制的理解。我们再次意识到披膜病毒引发发热性关节炎流行的可能性。丙型肝炎病毒在原发性混合性冷球蛋白血症中的发展情况促使我们探索特定抗病毒疗法的策略。疱疹病毒家族成员因其在干燥综合征中的作用而受到审视。逆转录病毒由于艾滋病患者出现的风湿性疾病综合征以及仍未明确的逆转录病毒可能在类风湿性关节炎中起病因作用的推测，继续吸引着人们的关注。本综述重点介绍了过去一年在阐明病毒感染在风湿性疾病中的作用方面所做的努力。
