Naides S J
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242.
Curr Opin Rheumatol. 1993 Jul;5(4):468-74. doi: 10.1097/00002281-199305040-00011.
Viruses have long been considered candidates for infectious etiologic agents or cofactors in the development of rheumatic diseases. The current epidemic of HIV infection has focused both scientific and lay interest on identifying such agents and understanding their role in precipitating and perpetuating disease. During 1992, the role of hepatitis C virus infection in cryoglobulinemia was further defined. Interest in members of the Herpesviridae family was raised. The potential for postvaccination rubella arthritis was popularized. Additional clinical presentations of parvovirus B19 infection were described. Studies in patients and in vitro continued to provide tantalizing clues to the possible role of retroviruses, both exogenous and endogenous, in rheumatic disease. This review highlights efforts made during the past year to elucidate the role of viral infection in rheumatologic disease.
长期以来，病毒一直被视为风湿性疾病发展过程中感染性病因或辅助因素的候选者。当前的艾滋病毒感染流行，使科学界和普通大众都关注于识别此类病原体，并了解它们在疾病引发和持续发展中所起的作用。1992年期间，丙型肝炎病毒感染在冷球蛋白血症中的作用得到了进一步明确。人们对疱疹病毒科成员的兴趣有所增加。接种疫苗后发生风疹性关节炎的可能性受到广泛关注。有人描述了细小病毒B19感染的更多临床表现。针对患者和体外研究继续为外源性和内源性逆转录病毒在风湿性疾病中可能发挥的作用提供了诱人线索。本综述重点介绍了过去一年中为阐明病毒感染在风湿性疾病中的作用所做的努力。
