Cain B E, Corpron R E, Fee C L, Strachan D S, Kowalski C J
School of Dentistry, University of Michigan, Ann Arbor 48109-1078.
Caries Res. 1994;28(4):284-90. doi: 10.1159/000261987.
Dose-related remineralization of enamel lesions was studied in situ. Enamel specimens with subsurface lesions were mounted on lower molars bilaterally and exposed to five regimens: (A) control with a F-free dentifrice three times daily; (B) NaF dentifrice brushed three times daily; (C) fluoride-releasing device (FRD; 0.07 mg F/day release rate) plus F-free dentifrice; (D) FRD (0.232 mg F/day) plus F-free dentifrice, F/day and (E) FRD (0.232 mg/F/day) plus NaF dentifrice. Resting and stimulated saliva samples were obtained for salivary flow and F content determinations. Twenty-eight subjects participated in this double-blind, random-assignment crossover study. After 50 days the enamel specimens were recovered, sectioned, microradiographed, and scanned with image analysis. Regimens D and E demonstrated approximately 30% additional remineralization as compared with to controls, and regimens B and C showed 13.7 and 10.5% increased remineralization as compared with to controls. The increased remineralization of the regimens generally paralleled the increase in salivary F and clearly demonstrated a dose-related response which was some threefold in relation to release rate, salivary F, and percent remineralization.
在原位研究了牙釉质病变的剂量相关再矿化情况。将具有表层下病变的牙釉质标本双侧安装在下颌磨牙上，并暴露于五种方案中：(A) 每天三次使用不含氟的牙膏作为对照；(B) 每天三次使用含氟化钠的牙膏刷牙；(C) 释氟装置（FRD；释放速率为0.07毫克氟/天）加不含氟的牙膏；(D) FRD（0.232毫克氟/天）加不含氟的牙膏；以及 (E) FRD（0.232毫克氟/天）加含氟化钠的牙膏。采集静息和刺激后的唾液样本以测定唾液流量和氟含量。28名受试者参与了这项双盲、随机分配的交叉研究。50天后，回收牙釉质标本，进行切片、显微放射照相并用图像分析进行扫描。与对照组相比，方案D和E显示出约30%的额外再矿化，方案B和C与对照组相比，再矿化增加了13.7%和10.5%。各方案再矿化的增加通常与唾液氟的增加平行，并且清楚地显示出与释放速率、唾液氟和再矿化百分比相关的剂量反应，该反应在释放速率、唾液氟和再矿化百分比方面约为三倍。
