Zohar J, Kaplan Z, Benjamin J
Division of Psychiatry, Chaim Sheba Medical Center, Ramat Gan, Tel-Hashomer, Israel.
J Clin Psychiatry. 1994 Mar;55(3):86-8.
Paraphilias are psychosexual disorders that are usually conceptualized as deviant in nature. Yet in some cases, paraphilia can be conceptualized as an obsessive compulsive disorder.
We describe an exhibitionist treated under partial single-blind conditions (patient was blind to placebo but was aware he was receiving desipramine and fluvoxamine) with the serotonin selective reuptake inhibitor fluvoxamine, followed by desipramine and a placebo that looked like fluvoxamine, in an ABACA design. He was serially assessed with the Yale-Brown Obsessive Compulsive Scale.
Fluvoxamine eliminated the undesired impulse and behavior without affecting sexual desire. Desipramine and single-blind fluvoxamine-placebo treatment were both associated with relapses.
A subset of paraphiliacs may be suffering from obsessive-compulsive-related disorders and may benefit from serotonergic agents.
性偏好障碍是性心理障碍,通常在本质上被视为异常。然而在某些情况下,性偏好障碍可被视为一种强迫症。
我们描述了一名暴露癖患者,采用ABACA设计,在部分单盲条件下(患者对安慰剂不知情,但知道自己正在接受地昔帕明和氟伏沙明治疗)接受5-羟色胺选择性再摄取抑制剂氟伏沙明治疗,随后接受地昔帕明和外观类似氟伏沙明的安慰剂治疗。使用耶鲁-布朗强迫症量表对其进行连续评估。
氟伏沙明消除了不良冲动和行为,且未影响性欲。地昔帕明和单盲氟伏沙明-安慰剂治疗均与病情复发相关。
一部分性偏好障碍患者可能患有强迫症相关疾病,可能从5-羟色胺能药物中获益。