• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Glucokinase: structural analysis of a protein involved in susceptibility to diabetes.

作者信息

Pilkis S J, Weber I T, Harrison R W, Bell G I

机构信息

Department of Physiology and Biophysics, State University of New York, Stony Brook 11794-8661.

出版信息

J Biol Chem. 1994 Sep 2;269(35):21925-8.

PMID:8071309
Abstract
摘要

相似文献

1
Glucokinase: structural analysis of a protein involved in susceptibility to diabetes.葡萄糖激酶:一种与糖尿病易感性相关蛋白质的结构分析
J Biol Chem. 1994 Sep 2;269(35):21925-8.
2
Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase.单体变构酶人类葡萄糖激酶变构调节的结构基础。
Structure. 2004 Mar;12(3):429-38. doi: 10.1016/j.str.2004.02.005.
3
Biochemical characterization of MODY2 glucokinase variants V62M and G72R reveals reduced enzymatic activities relative to wild type.对 MODY2 葡萄糖激酶变异体 V62M 和 G72R 的生化特征分析表明,其相对于野生型的酶活性降低。
Biochemistry. 2009 Mar 24;48(11):2514-21. doi: 10.1021/bi900020n.
4
Glucokinase and non-insulin-dependent diabetes.葡萄糖激酶与非胰岛素依赖型糖尿病
Clin Endocrinol (Oxf). 1993 Jul;39(1):17-9. doi: 10.1111/j.1365-2265.1993.tb01745.x.
5
Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2).突变型β细胞葡萄糖激酶的结构不稳定性:对青年发病型成年糖尿病(2型)分子发病机制的影响。
Biochem J. 1997 Feb 15;322 ( Pt 1)(Pt 1):57-63. doi: 10.1042/bj3220057.
6
Glucokinase (GCK) and other susceptibility genes for beta-cell dysfunction: the candidate approach.葡萄糖激酶(GCK)及其他β细胞功能障碍的易感基因:候选基因研究方法
Biochem Soc Trans. 2008 Jun;36(Pt 3):306-11. doi: 10.1042/BST0360306.
7
GCK-MODY diabetes as a protein misfolding disease: the mutation R275C promotes protein misfolding, self-association and cellular degradation.GCK-MODY 糖尿病作为一种蛋白质错误折叠疾病:突变 R275C 促进蛋白质错误折叠、自身聚集和细胞降解。
Mol Cell Endocrinol. 2014 Jan 25;382(1):55-65. doi: 10.1016/j.mce.2013.08.020. Epub 2013 Aug 31.
8
[Glucokinase and non-insulin-dependent diabetes: from gene to disease].[葡萄糖激酶与非胰岛素依赖型糖尿病:从基因到疾病]
Journ Annu Diabetol Hotel Dieu. 1993:51-61.
9
Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1932-6. doi: 10.1073/pnas.90.5.1932.
10
Hormonal and Metabolite Regulation of Hepatic Glucokinase.肝葡萄糖激酶的激素和代谢物调节。
Annu Rev Nutr. 2016 Jul 17;36:389-415. doi: 10.1146/annurev-nutr-071715-051145. Epub 2016 May 4.

引用本文的文献

1
Glucokinase (GCK) in diabetes: from molecular mechanisms to disease pathogenesis.葡萄糖激酶(GCK)在糖尿病中的作用:从分子机制到疾病发病机制。
Cell Mol Biol Lett. 2024 Sep 8;29(1):120. doi: 10.1186/s11658-024-00640-3.
2
Glucose transporters in pancreatic islets.胰岛中的葡萄糖转运蛋白。
Pflugers Arch. 2020 Sep;472(9):1249-1272. doi: 10.1007/s00424-020-02383-4. Epub 2020 May 12.
3
Enhanced Diffusion of Catalytically Active Enzymes.催化活性酶的扩散增强
ACS Cent Sci. 2019 Jun 26;5(6):939-948. doi: 10.1021/acscentsci.9b00228. Epub 2019 May 15.
4
Glycogen metabolism in humans.人类的糖原代谢
BBA Clin. 2016 Feb 27;5:85-100. doi: 10.1016/j.bbacli.2016.02.001. eCollection 2016 Jun.
5
Solution NMR Spectroscopy for the Study of Enzyme Allostery.用于研究酶变构作用的溶液核磁共振波谱法。
Chem Rev. 2016 Jun 8;116(11):6323-69. doi: 10.1021/acs.chemrev.5b00541. Epub 2016 Jan 6.
6
Cloning and characterization of feline islet glucokinase.猫胰岛葡萄糖激酶的克隆与特性分析
BMC Vet Res. 2014 Jun 10;10:130. doi: 10.1186/1746-6148-10-130.
7
Ingestion of a moderate high-sucrose diet results in glucose intolerance with reduced liver glucokinase activity and impaired glucagon-like peptide-1 secretion.摄入适量高蔗糖饮食会导致葡萄糖不耐受,肝葡萄糖激酶活性降低,胰高血糖素样肽-1 分泌受损。
J Diabetes Investig. 2012 Oct 18;3(5):432-40. doi: 10.1111/j.2040-1124.2012.00208.x.
8
Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy.2 型糖尿病患者空腹和餐后高血糖的发病机制:对治疗的启示。
Diabetes. 2010 Nov;59(11):2697-707. doi: 10.2337/db10-1032. Epub 2010 Aug 12.
9
Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis.人葡萄糖激酶的赖氨酸169是葡萄糖磷酸化的决定因素:对葡萄糖激酶催化的原子机制的启示。
PLoS One. 2009 Jul 20;4(7):e6304. doi: 10.1371/journal.pone.0006304.
10
A model for carbohydrate metabolism in the diatom Phaeodactylum tricornutum deduced from comparative whole genome analysis.基于比较全基因组分析推导的三角褐指藻碳水化合物代谢模型。
PLoS One. 2008 Jan 9;3(1):e1426. doi: 10.1371/journal.pone.0001426.