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1
Genetic analysis of drug resistance in Neisseria gonorrhoeae: identification and linkage relationships of loci controlling drug resistance.淋病奈瑟菌耐药性的遗传分析：控制耐药性的基因座的鉴定及连锁关系
Antimicrob Agents Chemother. 1975 May;7(5):676-81. doi: 10.1128/AAC.7.5.676.
2
Genetic mapping of linked antibiotic resistance loci in Neisseria gonorrhoeae.淋病奈瑟菌中相关抗生素抗性基因座的遗传图谱分析
J Bacteriol. 1974 Dec;120(3):1284-92. doi: 10.1128/jb.120.3.1284-1292.1974.
3
Genetic analysis of drug resistance in Neisseria gonorrhoeae: production of increased resistance by the combination of two antibiotic resistance loci.淋病奈瑟菌耐药性的遗传分析：两个抗生素耐药基因座组合导致耐药性增强
J Bacteriol. 1975 Nov;124(2):834-42. doi: 10.1128/jb.124.2.834-842.1975.
4
Transfer of antibiotic resistance in mixed cultures of Neisseria gonorrhoeae.淋病奈瑟菌混合培养物中抗生素耐药性的转移
J Infect Dis. 1974 Dec;130(6):660-3. doi: 10.1093/infdis/130.6.660.
5
Genetics of serum resistance in Neisseria gonorrhoeae: the sac-1 genetic locus.淋病奈瑟菌血清抗性的遗传学：sac-1基因座
Infect Immun. 1981 May;32(2):547-52. doi: 10.1128/iai.32.2.547-552.1981.
6
Mutation in a locus linked to penB-nmp causes suppression of the Mtr phenotype of Neisseria gonorrhoeae.与penB - nmp相关位点的突变导致淋病奈瑟菌Mtr表型的抑制。
Antimicrob Agents Chemother. 1988 Jul;32(7):971-7. doi: 10.1128/AAC.32.7.971.
7
Antibiotic resistance in Neisseria gonorrhoeae: genetics and mechanisms of resistance.淋病奈瑟菌的抗生素耐药性：耐药性的遗传学与机制
Sex Transm Dis. 1988 Oct-Dec;15(4):217-24. doi: 10.1097/00007435-198810000-00008.
8
Identification of drug resistance loci in various clinical isolates of Neisseria gonorrhoeae.淋病奈瑟菌不同临床分离株中耐药位点的鉴定
Antimicrob Agents Chemother. 1977 Sep;12(3):444-6. doi: 10.1128/AAC.12.3.444.
9
Chromosomal location of antibiotic resistance genes in Neisseria gonorrhoeae.淋病奈瑟菌中抗生素抗性基因的染色体定位
J Bacteriol. 1976 Mar;125(3):1207-10. doi: 10.1128/jb.125.3.1207-1210.1976.
10
Inheritance of low-level resistance to penicillin, tetracycline, and chloramphenicol in Neisseria gonorrhoeae.淋病奈瑟菌对青霉素、四环素和氯霉素低水平耐药性的遗传
J Bacteriol. 1975 Nov;124(2):740-9. doi: 10.1128/jb.124.2.740-749.1975.

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1
A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection.一种淋球菌外排泵系统可提高细菌在雌性小鼠生殖道感染模型中的存活率。
Infect Immun. 2003 Oct;71(10):5576-82. doi: 10.1128/IAI.71.10.5576-5582.2003.
2
Characterization of atypical aerobic gram-negative cocci isolated from humans.从人类分离出的非典型需氧革兰氏阴性球菌的特性分析。
J Clin Microbiol. 1982 May;15(5):906-14. doi: 10.1128/jcm.15.5.906-914.1982.
3
Penicillin-binding proteins of penicillin-susceptible and intrinsically resistant Neisseria gonorrhoeae.青霉素敏感和天然耐药淋病奈瑟菌的青霉素结合蛋白
Antimicrob Agents Chemother. 1980 Nov;18(5):730-7. doi: 10.1128/AAC.18.5.730.
4
Neisseria gonorrhoeae isolates from Ethiopia 2. Pair correlations between minimal inhibitory concentration values of five antibiotics and frequency of multiple antibiotic resistance.来自埃塞俄比亚的淋病奈瑟菌分离株2。五种抗生素的最小抑菌浓度值与多重耐药频率之间的配对相关性。
Bull World Health Organ. 1980;58(1):73-9.
5
The roles of sexual and asexual gene transfer in emergence of antibiotic resistant gonococci.性基因转移和无性基因转移在耐抗生素淋病奈瑟菌出现中的作用。
Trans Am Clin Climatol Assoc. 1986;97:60-8.
6
Genetic analysis of spontaneous resistance to ampicillin in Neisseria gonorrhoeae.淋病奈瑟菌对氨苄西林自发耐药性的遗传分析。
Antimicrob Agents Chemother. 1985 Jul;28(1):21-7. doi: 10.1128/AAC.28.1.21.
7
Chromosomal resistance of gonococci to antibiotics.淋球菌对抗生素的染色体耐药性。
Genitourin Med. 1987 Aug;63(4):239-43. doi: 10.1136/sti.63.4.239.
8
Genetic analysis and penicillin-binding protein alterations in Neisseria gonorrhoeae with chromosomally mediated resistance.具有染色体介导耐药性的淋病奈瑟菌的基因分析及青霉素结合蛋白改变
Antimicrob Agents Chemother. 1986 Nov;30(5):649-52. doi: 10.1128/AAC.30.5.649.
9
Vancomycin hypersusceptibility in Neisseria gonorrhoeae isolated from patients involves diverse mutations.从患者中分离出的淋病奈瑟菌对万古霉素超敏涉及多种突变。
Antimicrob Agents Chemother. 1986 Apr;29(4):687-95. doi: 10.1128/AAC.29.4.687.
10
Beta-lactamase plasmids and chromosomally mediated antibiotic resistance in pathogenic Neisseria species.致病性奈瑟菌属中的β-内酰胺酶质粒与染色体介导的抗生素耐药性
Clin Microbiol Rev. 1989 Apr;2 Suppl(Suppl):S125-33. doi: 10.1128/CMR.2.Suppl.S125.

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Multiple antibiotic resistance in Neisseria gonorrhoeae.淋病奈瑟菌的多重抗生素耐药性。
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STUDIES ON TRANSFORMATION IN MORAXELLA AND ORGANISMS ASSUMED TO BE RELATED TO MORAXELLA. 1. A METHOD FOR QUANTITATIVE TRANSFORMATION IN MORAXELLA AND NEISSERIA, WITH STREPLOMYCIN RESISTANCE AS THE GENETIC MARKER.关于莫拉克斯氏菌及假定与莫拉克斯氏菌相关的微生物转化的研究。1. 以链霉素抗性作为遗传标记的莫拉克斯氏菌和奈瑟氏菌定量转化方法。
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Studies on transformations of Hemophilus influenzae. IV. Linked and unlinked transformations.流感嗜血杆菌转化的研究。IV. 连锁与非连锁转化。
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Studies on transformations of Hemophilus influenzae. II. The molecular weight of transforming DNA by sedimentation and diffusion measurements.流感嗜血杆菌转化研究。II. 通过沉降和扩散测量确定转化DNA的分子量
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Genetic and physical map of the chromosome of Hemophilus influenzae.
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Single-dose antibiotic treatment of asymptomatic gonorrhea in hospitalized women.住院女性无症状淋病的单剂量抗生素治疗。
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Relationships between the sensitivities in vitro of Neisseria gonorrhoeae to spiramycin, penicillin, streptomycin, tetracycline, and erythromycin.淋病奈瑟菌对螺旋霉素、青霉素、链霉素、四环素和红霉素的体外敏感性之间的关系。
Br J Vener Dis. 1969 Sep;45(3):223-7. doi: 10.1136/sti.45.3.223.
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Genetic transformation of Neisseria gonorrhoeae to streptomycin resistance.淋病奈瑟菌向链霉素抗性的遗传转化。
J Bacteriol. 1966 Nov;92(5):1364-71. doi: 10.1128/jb.92.5.1364-1371.1966.
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Inhibitors of ribosome functions.核糖体功能抑制剂。
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Resistance of Escherichia coli to penicillins. IX. Genetics and physiology of class II ampicillin-resistant mutants that are galactose negative or sensitive to bacteriophage C21, or both.大肠杆菌对青霉素的抗性。IX. 对噬菌体C21呈半乳糖阴性或敏感或两者兼具的II类氨苄青霉素抗性突变体的遗传学和生理学特性
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淋病奈瑟菌耐药性的遗传分析：控制耐药性的基因座的鉴定及连锁关系

Genetic analysis of drug resistance in Neisseria gonorrhoeae: identification and linkage relationships of loci controlling drug resistance.

作者信息

Maier T W, Zubrzycki L, Coyle M B

出版信息

Antimicrob Agents Chemother. 1975 May;7(5):676-81. doi: 10.1128/AAC.7.5.676.

DOI:10.1128/AAC.7.5.676
PMID:807159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429202/
Abstract

The genetic basis of multiple drug resistance of Neisseria gonorrhoeae was investigated by the technique of transformation. Six different genetic loci were characterized by the type and amount of antibiotic resistance they controlled, and also by the degree of linkage to other resistance markers. A streptomycin resistance locus is linked to separate loci determining resistance to tetracycline, chloramphenicol, and erythromycin. A multiple resistance locus was identified. This genetic locus determines resistance to a variety of antibacterial agents. Lastly, a locus determining resistance to the penicillins was found which is unlinked to any other resistance locus.

摘要

采用转化技术研究了淋病奈瑟菌多重耐药的遗传基础。通过它们所控制的抗生素耐药类型和数量，以及与其他耐药标记的连锁程度，对六个不同的基因位点进行了表征。一个链霉素耐药位点与决定对四环素、氯霉素和红霉素耐药的不同位点相连。鉴定出一个多重耐药位点。该基因位点决定对多种抗菌剂的耐药性。最后，发现了一个决定对青霉素耐药的位点，它与任何其他耐药位点均无连锁关系。