淋病奈瑟菌耐药性的遗传分析：控制耐药性的基因座的鉴定及连锁关系
Genetic analysis of drug resistance in Neisseria gonorrhoeae: identification and linkage relationships of loci controlling drug resistance.
作者信息
Maier T W, Zubrzycki L, Coyle M B
出版信息
Antimicrob Agents Chemother. 1975 May;7(5):676-81. doi: 10.1128/AAC.7.5.676.
Abstract
The genetic basis of multiple drug resistance of Neisseria gonorrhoeae was investigated by the technique of transformation. Six different genetic loci were characterized by the type and amount of antibiotic resistance they controlled, and also by the degree of linkage to other resistance markers. A streptomycin resistance locus is linked to separate loci determining resistance to tetracycline, chloramphenicol, and erythromycin. A multiple resistance locus was identified. This genetic locus determines resistance to a variety of antibacterial agents. Lastly, a locus determining resistance to the penicillins was found which is unlinked to any other resistance locus.
摘要
采用转化技术研究了淋病奈瑟菌多重耐药的遗传基础。通过它们所控制的抗生素耐药类型和数量，以及与其他耐药标记的连锁程度，对六个不同的基因位点进行了表征。一个链霉素耐药位点与决定对四环素、氯霉素和红霉素耐药的不同位点相连。鉴定出一个多重耐药位点。该基因位点决定对多种抗菌剂的耐药性。最后，发现了一个决定对青霉素耐药的位点，它与任何其他耐药位点均无连锁关系。
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