Moriel E Z, Rajfer J
Department of Surgery, UCLA School of Medicine.
J Urol. 1993 May;149(5 Pt 2):1299-300. doi: 10.1016/s0022-5347(17)36373-5.
In an attempt to determine whether penile pain associated with intracorporeal injections could be due to the acidity of the medication, we performed a randomized study comparing the incidence of penile pain following intracorporeal injections with or without the addition of sodium bicarbonate to the intracorporeal medications. A total of 38 consecutive patients who presented to our clinic with impotence received 0.2 ml. of a combination of 3 drugs: 6 mg. papaverine, 100 micrograms. phentolamine and 10 micrograms. prostaglandin E1 with (pH 7.05) or without (pH 4.17) the addition of sodium bicarbonate (0.03 mEq.). Of the 19 patients without sodium bicarbonate added to the medication 11 (58%) complained of penile pain due to the medication, while only 1 of the 19 men (5%) who received sodium bicarbonate complained of penile pain. From these data we conclude that the penile pain following intracorporeal injections is most likely due to the acidity of the medication, which can be overcome by elevating the pH to a neutral level.
为了确定阴茎海绵体内注射相关的阴茎疼痛是否可能归因于药物的酸度，我们进行了一项随机研究，比较了在阴茎海绵体内药物中添加或不添加碳酸氢钠情况下阴茎海绵体内注射后阴茎疼痛的发生率。共有38例因阳痿前来我们诊所就诊的连续患者接受了0.2毫升由三种药物组成的合剂：6毫克罂粟碱、100微克酚妥拉明和10微克前列腺素E1，其中一组添加了碳酸氢钠（0.03毫当量，pH值7.05），另一组未添加（pH值4.17）。在未添加碳酸氢钠的19例患者中，11例（58%）因药物注射而抱怨阴茎疼痛，而在接受了碳酸氢钠的19例男性中，只有1例（5%）抱怨阴茎疼痛。根据这些数据我们得出结论，阴茎海绵体内注射后的阴茎疼痛很可能归因于药物的酸度，通过将pH值提高到中性水平可以克服这一问题。
