Greenwood R, Golding J, McCaw-Binns A, Keeling J, Ashley D
Institute of Child Health, University of Bristol, UK.
Paediatr Perinat Epidemiol. 1994 Apr;8 Suppl 1:143-57. doi: 10.1111/j.1365-3016.1994.tb00497.x.
Information from the Jamaican Perinatal Mortality Survey was used to identify features of mothers and their pregnancies that were independently associated with perinatal death. Social, biological, environmental, life style and medical aspects of mothers and their pregnancies were collected on two inter-locking subsamples: (1) all births on the island of Jamaica in the 2 months of September and October 1986, the 'cohort months', and (2) all fetal deaths of weight 500 g or more, together with all neonatal deaths, in the 12-month period from 1 September 1986 to 31 August 1987. Singleton survivors from the cohort months were compared with all perinatal deaths in the 12-month period using logistic regression. The first model omitted items concerning past obstetric history, but these were included in the second model. In total, 21 variables entered the first model and 24 the second. The only item that became non-significant when past obstetric history was included was maternal age. The final model compared 1017 perinatal deaths with 7672 survivors. It consisted of the following: union (marital) status (married being at lower risk, P < 0.01), maternal employment status (housewives at lowest risk, P < 0.001), number of adults in household (the more the higher the risk, P < 0.05), the number of children aged < 11 (the more the lower the risk, P < 0.0001), use of toilet facilities (shared with other households increased risk, P < 0.001), maternal height (tall women at reduced risk, P < 0.001), mother's report that she was trying to get pregnant (P < 0.001), maternal alcohol consumption (drinkers had lower risk, P < 0.05), maternal syphilis (higher risk, P < 0.0001), bleeding before 28 weeks (higher risk, P < 0.0001), bleeding at 28 weeks or more (higher risk, P < 0.0001), first diastolic blood pressure (80 mm + at higher risk, P < 0.0001), highest diastolic blood pressure (100 mm + at increased risk, P < 0.0001), highest proteinuria (++ or more at increased risk, P < 0.0001), vaginal discharge/infection (untreated at increased risk, P < 0.001), pre-eclampsia diagnosed in antenatal period (increased risk, P < 0.01), maternal diabetes (increased risk, P < 0.05), start of antenatal care (first trimester at reduced risk, P < 0.01), iron taken (reduced risk, P < 0.0001), type of perinatal care available in parish of residence (reduced risk if consultant obstetricians and paediatricians available at all times, P < 0.0001), number of miscarriages and terminations (the more the higher the risk, P < 0.0001), previous stillbirth (higher risk, P < 0.0001), previous early neonatal death (higher risk, P < 0.001), previous Caesarean section (higher risk, P < 0.01). The implications for reduction in perinatal mortality rates are discussed.
牙买加围产期死亡率调查所获信息被用于确定与围产期死亡独立相关的母亲及其孕期特征。母亲及其孕期的社会、生物学、环境、生活方式和医学方面的信息是通过两个相互关联的子样本收集的:(1)1986年9月和10月这两个月牙买加岛上的所有出生情况,即“队列月份”;(2)1986年9月1日至1987年8月31日这12个月期间所有体重500克及以上的胎儿死亡情况以及所有新生儿死亡情况。使用逻辑回归将队列月份中的单胎存活者与12个月期间的所有围产期死亡情况进行比较。第一个模型省略了与既往产科病史相关的项目,但这些项目包含在第二个模型中。总共有21个变量进入第一个模型,24个进入第二个模型。当纳入既往产科病史时,唯一变得不显著的项目是母亲年龄。最终模型将1017例围产期死亡与7672例存活者进行了比较。它包括以下内容:婚姻状况(已婚风险较低,P < 0.01)、母亲就业状况(家庭主妇风险最低,P < 0.001)、家庭中成年人数量(数量越多风险越高,P < 0.05)、11岁以下儿童数量(数量越多风险越低,P < 0.0001)、厕所设施使用情况(与其他家庭共用会增加风险,P < 0.001)、母亲身高(高个子女性风险降低,P < 0.001)、母亲报告她正在尝试怀孕(P < 0.001)、母亲饮酒情况(饮酒者风险较低,P < 0.05)、母亲梅毒感染情况(风险较高,P < 0.0001)、28周前出血情况(风险较高,P < 0.0001)、28周及以后出血情况(风险较高,P < 0.0001)、首次舒张压(80毫米汞柱及以上风险较高,P < 0.0001)、最高舒张压(100毫米汞柱及以上风险增加,P < 0.0001)、最高蛋白尿(++及以上风险增加,P < 0.0001)、阴道分泌物/感染情况(未治疗风险增加,P < 0.001)、产前诊断为子痫前期(风险增加,P < 0.01)、母亲糖尿病(风险增加,P < 0.05)、产前护理开始时间(孕早期风险降低)、服用铁剂情况(风险降低,P < 0.0001)、居住教区可获得的围产期护理类型(如果随时有产科顾问医生和儿科医生风险降低,P < 0.0001)、流产和终止妊娠次数(次数越多风险越高,P < 0.0001)、既往死产情况(风险较高,P < 0.0001)、既往早期新生儿死亡情况(风险较高,P < 0.001)、既往剖宫产情况(风险较高,P < 0.01)。文中还讨论了降低围产期死亡率的意义。