Greenwood R, Samms-Vaughan M, Golding J, Ashley D
Institute of Child Health, University of Bristol, UK.
Paediatr Perinat Epidemiol. 1994 Apr;8 Suppl 1:40-53. doi: 10.1111/j.1365-3016.1994.tb00490.x.
Singleton survivors born to multigravidae in the whole island of Jamaica in 2 months (September-October 1986) were compared with singleton perinatal deaths occurring to multigravidae throughout the island in the 12-month period September 1986 to August 1987. Past obstetric history was obtained from the mothers using a structured questionnaire. Deaths were categorised using the Wigglesworth classification. Logistic regression was used to compare current outcomes in women who had had at least one previous pregnancy. Antepartum fetal deaths with (1) outcome of last pregnancy; (2) previous Caesarean section; (3) previous stillbirth; and (4) increasing gravidity. In the presence of these factors maternal age ceased to be statistically significant. Deaths from immaturity were strongly associated with the past obstetric history, with increased risks for pregnancies to mothers with a history of previous miscarriage, perinatal death and premature live births. In general, however, the higher the gravidity the lower the risk. In the presence of these factors, maternal age showed no significant association. Intrapartum asphyxia was also associated with the outcome of the last pregnancy, history of prior stillbirth or neonatal death. First pregnancies were at significantly higher risk than second pregnancies (P < 0.05). For perinatal deaths as a whole, and in the presence of maternal age, the following were statistically significant independent factors: (1) the outcome of the immediately preceding pregnancy (high risks associated with prior miscarriage, stillbirth and premature live births); (2) previous Caesarean section (increased risk); (3) previous perinatal deaths; and (4) more than one prior early fetal loss. The results indicated that prior poor obstetric history bears similar risks of subsequent adverse outcome in the developing as in the developed world. There was no variation in risk, however, with interpregnancy interval or previous termination. Much of the variation in risk of perinatal death with maternal age among multigravidae appears largely to be secondary to past obstetric history.
将1986年9月至10月这两个月间牙买加全岛多产妇所生的单胎存活儿,与1986年9月至1987年8月这12个月间全岛多产妇发生的单胎围产期死亡情况进行了比较。通过结构化问卷从母亲那里获取既往产科病史。死亡情况按照威格尔斯沃思分类法进行分类。采用逻辑回归分析来比较至少有过一次既往妊娠的女性的当前结局。分析产前胎儿死亡与(1)上次妊娠结局;(2)既往剖宫产;()既往死产;以及(4)孕次增加之间的关系。在存在这些因素的情况下,母亲年龄不再具有统计学意义。未成熟所致死亡与既往产科病史密切相关,有过流产、围产期死亡和早产活产史的母亲再次怀孕时风险增加。然而,总体而言,孕次越高风险越低。在存在这些因素的情况下,母亲年龄未显示出显著关联。产时窒息也与上次妊娠结局、既往死产或新生儿死亡史有关。初孕的风险显著高于次孕(P<0.05)。对于总体围产期死亡情况,在考虑母亲年龄的情况下,以下因素是具有统计学意义的独立因素:(1)紧前一次妊娠的结局(与既往流产、死产和早产活产相关的高风险);(2)既往剖宫产(风险增加);(3)既往围产期死亡;以及(4)不止一次既往早期胎儿丢失。结果表明,既往不良产科病史在发展中国家和发达国家后续出现不良结局的风险相似。然而,风险并未因妊娠间隔或既往终止妊娠而有所变化。多产妇围产期死亡风险随母亲年龄的变化很大程度上似乎继发于既往产科病史。