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分枝杆菌的共同抗原和种特异性抗原在结核菌素皮肤反应中的参与情况。

The participation of common and species-"specific" antigens of Mycobacteria in the tuberculin skin reaction.

作者信息

Turcotte R

出版信息

Can J Microbiol. 1975 Jun;21(6):774-83. doi: 10.1139/m75-115.

DOI:10.1139/m75-115
PMID:807305
Abstract

Protoplasmic extracts isolated from four different species of mycobacteria contained common and species-specific antigens. Both the common and the specific antigens were involved in the elicitation of the tuberculin reaction in sensitized guinea pigs. The elimination of the common antigens from the extracts by means of cross absorption with heterologous mycobacterial antibodies led to preparations which, at the doses used in this study, elicited a cutaneous reaction in animals sensitized with the corresponding strains only. Moreover, the tuberculin activity of the common antigens was about the same in animals sensitized either with homologous or heterologous strains.

摘要

从四种不同分枝杆菌物种中分离出的原生质提取物含有共同抗原和物种特异性抗原。共同抗原和特异性抗原都参与了致敏豚鼠结核菌素反应的引发。通过用异源分枝杆菌抗体进行交叉吸收从提取物中去除共同抗原,得到的制剂在本研究使用的剂量下,仅在对相应菌株致敏的动物中引发皮肤反应。此外,共同抗原在对同源或异源菌株致敏的动物中的结核菌素活性大致相同。

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Can J Microbiol. 1975 Jun;21(6):774-83. doi: 10.1139/m75-115.
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引用本文的文献

1
Specific T-cell epitopes for immunoassay-based diagnosis of Mycobacterium tuberculosis infection.用于基于免疫测定法诊断结核分枝杆菌感染的特异性T细胞表位
J Clin Microbiol. 2004 Jun;42(6):2379-87. doi: 10.1128/JCM.42.6.2379-2387.2004.
2
Mycobacterial antigens: a review of their isolation, chemistry, and immunological properties.分枝杆菌抗原:其分离、化学性质及免疫学特性综述
Microbiol Rev. 1978 Mar;42(1):84-113. doi: 10.1128/mr.42.1.84-113.1978.