Krivopishin I P, Iurovitskiĭ Iu G, Mil'man L S
Ontogenez. 1976;7(6):598-604.
The marked changes in the activity and ratio of the active and inactive forms of glycogen synthetase and phosphorylase were found in the liver of developing chick embryo. The activity of phosphorylase increased in the liver from the 8th day of incubation till the end of embryogenesis. The practically complete activation of the inactive form of this enzyme was noted in the end of embryogenesis. The activity of glycogen synthetase in the liver increased till the 17th day of incubation and sharply decreased more than 6 times thereafter. The maximum of the active form of glycogen synthetase (1/3 of total activity) was noted on the 17th day as well. The changes in the content of glycogen synthetase in the liver are synchronized with those in the activity and ratio of the active and inactive forms of glycogen synthetase. The role of changes in the concentration of glucose and glucose-6-phosphate in the control of ratio of the active and inactive forms of enzymes of glycogen metabolism is discussed.
在发育中的鸡胚肝脏中，发现糖原合成酶和磷酸化酶的活性以及活性形式与非活性形式的比例有显著变化。从孵化第8天到胚胎发育结束，肝脏中磷酸化酶的活性增加。在胚胎发育末期，该酶的非活性形式几乎完全被激活。肝脏中糖原合成酶的活性在孵化第17天之前增加，此后急剧下降超过6倍。糖原合成酶活性形式的最大值（占总活性的1/3）也出现在第17天。肝脏中糖原合成酶含量的变化与糖原合成酶活性形式与非活性形式的活性及比例变化同步。讨论了葡萄糖和葡萄糖-6-磷酸浓度变化在糖原代谢酶活性形式与非活性形式比例控制中的作用。
