针对乳酸乳球菌的免疫反应：其作为疫苗递送载体的应用意义。
The immune response to Lactococcus lactis: implications for its use as a vaccine delivery vehicle.
作者信息
Norton P M, Brown H W, Le Page R W
机构信息
Department of Pathology, University of Cambridge, UK.
出版信息
FEMS Microbiol Lett. 1994 Jul 15;120(3):249-56. doi: 10.1111/j.1574-6968.1994.tb07041.x.
The development of natural antibodies to Lactococcus lactis in three inbred strains of mice and the effect of inoculating L. lactis into these mice has been investigated. All animals developed detectable levels of natural (systemic and secretory) anti-lactococcal antibodies. Systemic anti-lactococcal antibodies were principally IgG in young mice. An increase in anti-lactococcal IgM occurred in all older animals. Inoculation of L. lactis strains MG1820 or MG1363 by the oral and parenteral routes induced systemic anti-lactococcal antibody responses in a dose-dependent fashion. The relative immunogenicity of individual bacterial proteins varied according to mouse strain and route of inoculation.
研究了三种近交系小鼠体内针对乳酸乳球菌天然抗体的产生情况以及向这些小鼠接种乳酸乳球菌的效果。所有动物均产生了可检测水平的天然（全身性和分泌性）抗乳球菌抗体。幼鼠体内的全身性抗乳球菌抗体主要为IgG。所有老年动物体内的抗乳球菌IgM均有所增加。经口服和肠胃外途径接种乳酸乳球菌菌株MG1820或MG1363，会以剂量依赖方式诱导全身性抗乳球菌抗体反应。单个细菌蛋白的相对免疫原性因小鼠品系和接种途径而异。
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