Nagamachi S, Nishikawa T, Ono S, Ageta M, Matsuo T, Jinnouchi S, Hoshi H, Ohnishi T, Futami S, Watanabe K
Department of Radiology, Miyazaki Medical College, Japan.
Nucl Med Commun. 1994 Jun;15(6):455-60. doi: 10.1097/00006231-199406000-00010.
Regional cerebral blood flow (rCBF) was measured using N-isopropyl-123I-iodoamphetamine (123I-IMP) with single photon emission computed tomography (SPECT) in 27 patients with diabetes mellitus with an average age of 64.1 years and with an average fasting plasma glucose of 145 mg dl-1. Their data were compared with those of 12 non-diabetic subjects with an average age of 64.6 years. None had cerebral infarction on computed tomographic (CT) studies. There were no significant differences in the physiological or laboratory data between the diabetic and non-diabetic groups except for their fasting plasma glucose and HbA1c levels. A reference sampling method using continuous arterial blood sampling was employed to quantify the rCBF. The average rCBF in each region of the cerebrum and cerebellum was significantly lower in the diabetic group than in the non-diabetic group (P < 0.01). Although a definite cause was obscure, the rCBF of the diabetic patients was reduced even in the absence of findings indicative of cerebral infarction on a CT study.
采用N-异丙基-123I-碘安非他明（123I-IMP）和单光子发射计算机断层扫描（SPECT）对27例平均年龄64.1岁、平均空腹血糖为145mg/dl的糖尿病患者进行局部脑血流量（rCBF）测定。将他们的数据与12例平均年龄64.6岁的非糖尿病受试者的数据进行比较。计算机断层扫描（CT）检查均未发现脑梗死。除空腹血糖和糖化血红蛋白水平外，糖尿病组和非糖尿病组的生理或实验室数据无显著差异。采用连续动脉采血的参考采样方法对rCBF进行定量分析。糖尿病组大脑和小脑各区域的平均rCBF显著低于非糖尿病组（P<0.01）。尽管确切原因尚不清楚，但即使CT检查未发现脑梗死迹象，糖尿病患者的rCBF仍降低。
