Suthienkul O, Poomchart A, Kositanont U, Siripanichgon K, Vathanophas K
Department of Microbiology, Faculty of Public Health, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Asian Pac J Allergy Immunol. 1993 Dec;11(2):141-7.
A seroepidemiological study for determining serum antibodies to lipopolysaccharides (LPS) of Shigella flexneri using dot--ELISA was carried out in Krabi Province, Thailand, from January 1989 to December 1990. From 363 serum samples obtained from cord blood and from venous blood of the healthy persons aged from 6 months to over 50 years, 56% and 22%, respectively, were found to be positive for specific IgG and IgM antibodies to S. flexneri LPS. The IgG prevalence was initially detected at 3-4 years of age and then rose sharply with age. In contrast, IgM was detectable earlier, with much lower prevalence than that of IgG. The highest seroprevalence values were in the age groups 30-49 years for IgG and 15-19 years for IgM. The seroprevalence of S. flexneri infection was statistically higher among males, Buddhists, businessmen, and those with elementary education. S. flexneri infection was not associated with family income, home location, eating behaviour or water supply. These seroepidemiologic data demonstrated that most of the population in Krabi Province had been infected with S. flexneri.
1989年1月至1990年12月期间，在泰国甲米府开展了一项血清流行病学研究，采用斑点酶联免疫吸附测定法（dot-ELISA）检测福氏志贺菌脂多糖（LPS）的血清抗体。从363份取自脐带血和6个月至50岁以上健康人静脉血的血清样本中，分别发现56%和22%的样本针对福氏志贺菌LPS的特异性IgG和IgM抗体呈阳性。IgG阳性率最初在3至4岁时被检测到，随后随年龄急剧上升。相比之下，IgM检测得更早，其阳性率远低于IgG。IgG最高血清阳性率出现在30至49岁年龄组，IgM最高血清阳性率出现在15至19岁年龄组。在男性、佛教徒、商人以及接受过小学教育的人群中，福氏志贺菌感染的血清阳性率在统计学上更高。福氏志贺菌感染与家庭收入、居住地点、饮食行为或供水无关。这些血清流行病学数据表明，甲米府的大多数人群都曾感染过福氏志贺菌。
