灰色链霉菌产生放线菌酮：放线菌酮生物合成的调控机制。
Cycloheximide production by Streptomyces griseus: control mechanisms of cycloheximide biosynthesis.
作者信息
K'ominek L A
出版信息
Antimicrob Agents Chemother. 1975 Jun;7(6):856-6. doi: 10.1128/AAC.7.6.856.
Abstract
Cycloheximide accumulation in a fermentation medium has been shown to be the product of the balance between synthesis and degradation of this antibiotic. Glucose has been shown to prevent cycloheximide degradation. Cycloheximide has been shown to interfere with its own synthesis probably due to feedback inhibition. Approaches for increasing cycloheximide titers in the light of these findings are discussed.
摘要
发酵培养基中放线菌酮的积累已被证明是这种抗生素合成与降解之间平衡的产物。葡萄糖已被证明可防止放线菌酮降解。放线菌酮已被证明可能由于反馈抑制而干扰其自身的合成。根据这些发现，讨论了提高放线菌酮效价的方法。
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本文引用的文献
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