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Cycloheximide production by Streptomyces griseus: alleviation of end-product inhibition by dialysis-extraction fermentation.灰色链霉菌生产环己酰亚胺：通过透析萃取发酵减轻终产物抑制作用。
Antimicrob Agents Chemother. 1975 Jun;7(6):861-3. doi: 10.1128/AAC.7.6.861.
2
Cycloheximide production by Streptomyces griseus: control mechanisms of cycloheximide biosynthesis.灰色链霉菌产生放线菌酮：放线菌酮生物合成的调控机制。
Antimicrob Agents Chemother. 1975 Jun;7(6):856-6. doi: 10.1128/AAC.7.6.856.
3
Feedback regulation and the intracellular protein profile of Streptomyces griseus in a cycloheximide fermentation.
Appl Microbiol Biotechnol. 1990 Nov;34(2):191-7. doi: 10.1007/BF00166779.
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Production of cycloheximide by Streptomyces sp.
Acta Microbiol Pol B. 1972;4(2):83-8.
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Changes in the protein profile of Streptomyces griseus during a cycloheximide fermentation.
Ann N Y Acad Sci. 1987;506:511-22. doi: 10.1111/j.1749-6632.1987.tb23846.x.
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Efficient production of nonactin by Streptomyces griseus subsp. griseus.灰色链霉菌灰色亚种高效生产无活菌素。
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Selective strategies for antibiotic fermentation, Part II: Effect of aeration on streptomycin production by Streptomyces griseus JB-19.抗生素发酵的选择性策略，第二部分：通气对灰色链霉菌JB - 19产生链霉素的影响
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Control of antibiotic biosynthesis.抗生素生物合成的控制
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Feedback regulation and the intracellular protein profile of Streptomyces griseus in a cycloheximide fermentation.
Appl Microbiol Biotechnol. 1990 Nov;34(2):191-7. doi: 10.1007/BF00166779.
6
Cycloheximide production by Streptomyces griseus: control mechanisms of cycloheximide biosynthesis.灰色链霉菌产生放线菌酮：放线菌酮生物合成的调控机制。
Antimicrob Agents Chemother. 1975 Jun;7(6):856-6. doi: 10.1128/AAC.7.6.856.

本文引用的文献

1
Dialysis Fermentor Systems for Concentrated Culture of Microorganisms.用于微生物浓缩培养的透析发酵罐系统
Appl Microbiol. 1963 Nov;11(6):506-12. doi: 10.1128/am.11.6.506-512.1963.
2
DIALYSIS FLASK FOR CONCENTRATED CULTURE OF MICROORGANISMS.用于微生物浓缩培养的透析烧瓶
J Bacteriol. 1963 Nov;86(5):919-29. doi: 10.1128/jb.86.5.919-929.1963.
3
Differential dialysis culture for separation and concentration of a macromolecular product.用于分离和浓缩大分子产物的微分透析培养法。
Appl Microbiol. 1967 Sep;15(5):1192-7. doi: 10.1128/am.15.5.1192-1197.1967.
4
Growth and acid production by Lactobacillus (L) delbrueckii in a dialysis culture system.
Biotechnol Bioeng. 1970 Nov;12(6):961-74. doi: 10.1002/bit.260120608.
5
Cycloheximide production by Streptomyces griseus: control mechanisms of cycloheximide biosynthesis.灰色链霉菌产生放线菌酮：放线菌酮生物合成的调控机制。
Antimicrob Agents Chemother. 1975 Jun;7(6):856-6. doi: 10.1128/AAC.7.6.856.

灰色链霉菌生产环己酰亚胺：通过透析萃取发酵减轻终产物抑制作用。

Cycloheximide production by Streptomyces griseus: alleviation of end-product inhibition by dialysis-extraction fermentation.

作者信息

Kominek L A

出版信息

Antimicrob Agents Chemother. 1975 Jun;7(6):861-3. doi: 10.1128/AAC.7.6.861.

DOI:10.1128/AAC.7.6.861
PMID:808160
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429241/
Abstract

The use of dialysis fermentation with the continuous extraction of the dialysate has resulted in a twofold increase in the cycloheximide titer due to relief from product inhibition. Continuous extraction of the dialysate has eliminated the necessity for large reservoir volumes of fermentation medium normally used in dialysis fermentation. The apparatus used in this procedure is described.

摘要

采用透析发酵并连续提取透析液，由于解除了产物抑制，放线菌酮效价提高了两倍。连续提取透析液消除了透析发酵中通常需要大量发酵培养基储存体积的必要性。描述了该过程中使用的装置。