灰色链霉菌生产环己酰亚胺：通过透析萃取发酵减轻终产物抑制作用。
Cycloheximide production by Streptomyces griseus: alleviation of end-product inhibition by dialysis-extraction fermentation.
作者信息
Kominek L A
出版信息
Antimicrob Agents Chemother. 1975 Jun;7(6):861-3. doi: 10.1128/AAC.7.6.861.
Abstract
The use of dialysis fermentation with the continuous extraction of the dialysate has resulted in a twofold increase in the cycloheximide titer due to relief from product inhibition. Continuous extraction of the dialysate has eliminated the necessity for large reservoir volumes of fermentation medium normally used in dialysis fermentation. The apparatus used in this procedure is described.
摘要
采用透析发酵并连续提取透析液，由于解除了产物抑制，放线菌酮效价提高了两倍。连续提取透析液消除了透析发酵中通常需要大量发酵培养基储存体积的必要性。描述了该过程中使用的装置。
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本文引用的文献
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DIALYSIS FLASK FOR CONCENTRATED CULTURE OF MICROORGANISMS.用于微生物浓缩培养的透析烧瓶
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Differential dialysis culture for separation and concentration of a macromolecular product.用于分离和浓缩大分子产物的微分透析培养法。
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Cycloheximide production by Streptomyces griseus: control mechanisms of cycloheximide biosynthesis.灰色链霉菌产生放线菌酮：放线菌酮生物合成的调控机制。
Antimicrob Agents Chemother. 1975 Jun;7(6):856-6. doi: 10.1128/AAC.7.6.856.
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