Muscat J E, Stellman S D, Wynder E L
Division of Epidemiology, American Health Foundation, New York, New York 10017.
Cancer. 1994 Oct 1;74(7):1847-54. doi: 10.1002/1097-0142(19941001)74:7<1847::aid-cncr2820740704>3.0.co;2-#.
The association between the use of nonsteroidal antiinflammatory drugs (NSAID) and large bowel cancer was examined in a hospital-based case-control study of 511 patients with colorectal cancer and 500 age-sex matched control subjects.
Regular NSAID use was defined as at least 3 times per week for 1 or more years before the date of hospital admission. Odds ratios (OR) were calculated by the duration of NSAID use and according to the medical reasons given for taking NSAIDs.
The prevalences of regular NSAID use were 15% for male patients, 8% for female patients, and 20% for control subjects. Overall, NSAID use was associated with a statistically significant risk reduction in men (OR = 0.64; 95% confidence interval [CI], 0.42-0.97) and in women (OR = 0.32; 95% CI, 0.18-0.57). The estimate decreased with duration among men but increased with duration among women. The risk reduction among patients who took NSAIDs to prevent heart disease was 0.67 (95% CI, 0.38-1.13) for men and 0.43 (95% CI, 0.12-1.59) for women. For treating headache pain, the OR was 0.5 (95% CI, 0.23-1.09) for men and 0.64 (95% CI, 0.25-1.62) for women. The use of NSAID was not found to be associated with the stage of cancer at diagnosis. The OR for daily acetaminophen use was 1.07 (95% CI, 0.35-3.23) for men and 0.59 (95% CI, 0.27-1.25) for women.
The regular use of NSAIDs was associated with an overall significant risk reduction of colorectal cancer in men and in women. Among female patients, the greater protective effect associated with short term NSAID use compared with long term NSAID use may reflect a sampling bias.
在一项基于医院的病例对照研究中，对511例结直肠癌患者和500名年龄与性别匹配的对照者进行了非甾体抗炎药（NSAID）使用与大肠癌之间关联的研究。
将入院日期前至少每周3次、持续1年或更长时间的NSAID常规使用定义为常规使用。根据NSAID的使用持续时间并按照服用NSAID的医学原因计算比值比（OR）。
男性患者、女性患者和对照者中NSAID常规使用率分别为15%、8%和20%。总体而言，NSAID的使用在男性（OR = 0.64；95%置信区间[CI]，0.42 - 0.97）和女性（OR = 0.32；95% CI，0.18 - 0.57）中与统计学上显著的风险降低相关。男性中的估计值随持续时间降低，而女性中则随持续时间增加。服用NSAID预防心脏病的患者中，男性的风险降低为0.67（95% CI，0.38 - 1.13），女性为0.43（95% CI，0.12 - 1.59）。对于治疗头痛，男性的OR为0.5（95% CI，0.23 - 1.09），女性为0.64（95% CI，0.25 - 1.62）。未发现NSAID的使用与诊断时的癌症分期相关。男性每日使用对乙酰氨基酚的OR为1.07（95% CI，0.35 - 3.23），女性为0.59（95% CI，0.27 - 1.25）。
NSAID的常规使用与男性和女性结直肠癌总体显著的风险降低相关。在女性患者中，与长期使用NSAID相比，短期使用NSAID具有更大的保护作用，这可能反映了抽样偏差。
