Rosenberg L, Palmer J R, Zauber A G, Warshauer M E, Stolley P D, Shapiro S
School of Public Health, Boston University School of Medicine, Brookline, MA 02146.
J Natl Cancer Inst. 1991 Mar 6;83(5):355-8. doi: 10.1093/jnci/83.5.355.
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin synthesis and tumor growth in the rodent colon. We assessed NSAID use in relation to risk of human large-bowel cancer in a hospital-based, case-control study of 1326 patients with colorectal cancer and 4891 control patients. For regular NSAID use that continued into the year before interview, the multivariate relative risk estimate was 0.5 (95% confidence interval, 0.4 to 0.8); the estimate decreased as the duration of use increased, but the trend was not statistically significant. Similar results were obtained whether cancer or non-cancer controls were used, and the inverse association was apparent for both colon cancer and rectal cancer in men and women and in subjects younger and older than 60 years. Regular NSAID use that had been discontinued at least 1 year previously and non-regular use were not associated with risk. Almost all regular NSAID use was of aspirin-containing drugs. The present data suggest that the sustained use of NSAIDs reduces the incidence of human large-bowel cancer.
非甾体抗炎药（NSAIDs）可抑制啮齿动物结肠中前列腺素的合成及肿瘤生长。在一项基于医院的病例对照研究中，我们评估了1326例结直肠癌患者和4891例对照患者使用NSAIDs与人类患大肠癌风险之间的关系。对于持续到访谈前一年的规律使用NSAIDs的情况，多变量相对风险估计值为0.5（95%置信区间为0.4至0.8）；该估计值随着使用时间的增加而降低，但该趋势无统计学意义。无论使用癌症对照还是非癌症对照，均得到类似结果，且在男性和女性以及60岁及以上和60岁以下的受试者中，结肠癌和直肠癌均呈现明显的负相关。至少在1年前已停用的规律使用NSAIDs以及不规律使用与风险均无关联。几乎所有规律使用的NSAIDs均为含阿司匹林的药物。目前的数据表明，持续使用NSAIDs可降低人类大肠癌的发病率。
