Frei B
Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts 02118.
Am J Med. 1994 Sep 26;97(3A):5S-13S; discussion 22S-28S. doi: 10.1016/0002-9343(94)90292-5.
This article is a brief overview of the mechanisms of production of reactive oxygen species in biologic systems, and the various antioxidant defense systems that provide protection against oxidative damage to biologic macromolecules. The mechanisms of lipid peroxidation and antioxidant protection are explained using a specific example, viz., oxidative modification of human low density lipoprotein and its prevention by vitamin C, vitamin E, and beta-carotene.
本文简要概述了生物系统中活性氧物种的产生机制，以及各种抗氧化防御系统，这些系统可保护生物大分子免受氧化损伤。利用一个具体例子，即人低密度脂蛋白的氧化修饰以及维生素C、维生素E和β-胡萝卜素对其的预防，解释了脂质过氧化和抗氧化保护的机制。
