Goldberger S, Sarraf D, Bernstein J M, Hurwitz J J
Department of Ophthalmology, Ophthalmic Plastic Surgery Service, University of Toronto, Mount Sinai Hospital, Ontario, Canada.
Ophthalmic Plast Reconstr Surg. 1994 Jun;10(2):80-6. doi: 10.1097/00002341-199406000-00002.
Involvement of the eyebrow fat pad in Graves' disease has never been reported. We noted that Graves' orbitopathy patients had bulkier eyebrows due to a larger eyebrow fat pad not associated with the preaponeurotic fat. A cadaver model was used to show that the eyebrow fat could be identified with magnetic resonance imaging (MRI) scans. Then, a series of Graves' orbitopathy patients were sent for orbital MRI scans, and the eyebrow fat was measured with maximum lengths and widths. The averages were compared to two groups of patients, one without orbital pathology, and one with orbital pathology causing proptosis but not due to Graves' disease. Graves' patients with early orbitopathy and incipient optic neuropathy or congestive orbits where optic neuropathy had to be ruled out had statistically significant larger eyebrow fat pads than either comparison group. This has clinical significance: The eyebrow fat may need to be debulked during operations such as blepharoplasty. Furthermore, periorbital fat may play a larger role in the disease process than previously thought.
眉毛脂肪垫与格雷夫斯病的关联此前从未有过报道。我们注意到，格雷夫斯眼眶病患者的眉毛因眉脂肪垫较大而显得更浓密，且该脂肪垫与眶隔前脂肪无关。我们使用尸体模型来证明，通过磁共振成像（MRI）扫描可以识别出眉毛脂肪。然后，对一系列格雷夫斯眼眶病患者进行眼眶MRI扫描，并测量眉毛脂肪的最大长度和宽度。将这些平均值与两组患者进行比较，一组无眼眶病变，另一组有导致眼球突出但非格雷夫斯病引起的眼眶病变。患有早期眼眶病且有早期视神经病变或充血性眼眶（必须排除视神经病变）的格雷夫斯病患者，其眉毛脂肪垫在统计学上显著大于两个对照组。这具有临床意义：在诸如眼睑成形术等手术过程中，可能需要去除部分眉毛脂肪。此外，眶周脂肪在疾病过程中可能比之前认为的发挥更大作用。
