Laufs R, Steinke H
J Natl Cancer Inst. 1975 Sep;55(3):649-51. doi: 10.1093/jnci/55.3.649.
A killed herpesvirus vaccine was prepared by inactivation of the oncogenic Herpesvirus ateles (HVA) with heat and formaldehyde. The vaccine proved safe in 9 marmosets (Saguinus oedipus) during a period of 461 days. The vaccinated marmosets developed high titers of serum antibodies against HVA and were resistant to 316 lethal dose 50 (LD50) cell-free HVA; the nonvaccinated control monkeys died of malignant lymphoma. The 5 challenged monkeys are clinically well and have now been under observation for 362 days.
一种灭活疱疹病毒疫苗是通过用加热和甲醛处理致癌的蜘蛛猴疱疹病毒（HVA）制备而成。在461天的时间里，该疫苗在9只狨猴（普通狨猴）身上被证明是安全的。接种疫苗的狨猴产生了高滴度的抗HVA血清抗体，并对316个致死剂量50（LD50）的无细胞HVA具有抗性；未接种疫苗的对照猴子死于恶性淋巴瘤。5只受挑战的猴子临床状况良好，目前已接受观察362天。
