Gómez G, Lagakos S W
Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya, Barcelona, Spain.
Biometrics. 1994 Mar;50(1):204-12.
We consider the nonparametric estimation of the time to infection with HIV and the latency period between infection and the onset of AIDS in data where both the events of infection and AIDS are not directly observed. The methods use self-consistency equations that are more easily and quickly solvable than the nonparametric estimators proposed by De Gruttola and Lagakos (1989, Biometrics 45, 1-11). The techniques are illustrated with data on hemophiliacs who became infected through contamination of the blood factor they were given to control their hemophilia.
我们考虑在未直接观察到感染和艾滋病发病这两个事件的数据中，对感染艾滋病毒的时间以及感染与艾滋病发病之间的潜伏期进行非参数估计。这些方法使用了自洽方程，比起De Gruttola和Lagakos（1989年，《生物统计学》45卷，1 - 11页）提出的非参数估计量，它们更容易且更快求解。通过血友病患者的数据对这些技术进行了说明，这些患者因所输注用于控制血友病的血液因子受到污染而感染。
