Witteman A M, Akkerdaas J H, van Leeuwen J, van der Zee J S, Aalberse R C
Central Laboratory of The Netherlands, Red Cross Blood Transfusion Service, Amsterdam.
Int Arch Allergy Immunol. 1994 Sep;105(1):56-61. doi: 10.1159/000236803.
A monoclonal antibody to Dermatophagoides pteronyssinus is described that cross-reacts with an IgE-binding antigen present in insects, Crustacea (e.g. shrimp) and other invertebrates. By means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis, gel filtration and immunofluorescence it was shown that this monoclonal antibody presumably recognizes tropomyosin. Tropomyosin was shown to be involved in cross-reactivity between mite, shrimp and insects in shrimp-allergic patients.
本文描述了一种针对屋尘螨的单克隆抗体，该抗体与昆虫、甲壳纲动物（如虾）和其他无脊椎动物中存在的一种IgE结合抗原发生交叉反应。通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳、凝胶过滤和免疫荧光法表明，这种单克隆抗体可能识别原肌球蛋白。研究表明，原肌球蛋白与虾过敏患者中螨、虾和昆虫之间的交叉反应有关。
