Bartzokas C A, Johnson R, Jane M, Martin M V, Pearce P K, Saw Y
Wirral Hospital NHS Trust, Wirral, Merseyside.
BMJ. 1994;309(6953):506-8. doi: 10.1136/bmj.309.6953.506.
To investigate the source of infections associated with orthopaedic prostheses.
Analysis of four infections of prosthetic joints with case records; minimum inhibitory and minimum bactericidal concentrations and sodium dodecylsulphate polyacrylamide gel electrophoresis of the cell wall polypeptides of the Streptococcus sanguis isolates from the mouth and infected prostheses; examination of the patients' mouths for periodontal disease and caries.
Four adults (three men) aged 58-83.
For each patient the strain of S sanguis isolated from the mouth was indistinguishable from that isolated from the prosthesis. All patients had severe periodontal disease and caries.
The mouth was probably the source of bacterial infection in the prosthetic joints of these patients; the route of infection was possibly haematogenous. Incipient oral infection should be treated before joint replacement, and oral health should be maintained indefinitely.
调查与骨科假体相关的感染源。
对4例人工关节感染病例进行病例记录分析；测定从口腔和感染假体分离出的血链球菌的最低抑菌浓度和最低杀菌浓度，并对其细胞壁多肽进行十二烷基硫酸钠聚丙烯酰胺凝胶电泳；检查患者口腔是否患有牙周病和龋齿。
4名成年人（3名男性），年龄在58 - 83岁之间。
对于每位患者，从口腔分离出的血链球菌菌株与从假体分离出的菌株无法区分。所有患者均患有严重的牙周病和龋齿。
口腔可能是这些患者人工关节细菌感染的来源；感染途径可能是血源性的。在进行关节置换前应治疗初期口腔感染，并应长期保持口腔健康。
