Jenkins S, Addy M, Newcombe R G
Department of Periodontology, Dental School, University of Wales College of Medicine, Cardiff, England.
J Clin Periodontol. 1994 Jul;21(6):441-4. doi: 10.1111/j.1600-051x.1994.tb00743.x.
A relatively small number of agents are used in mouthrinse products, although the possible variability in the final formulations is enormous. The aim of this study was to compare equal concentrations of 3 antimicrobial agents, in simple formulations, for plaque inhibition. This 4-day plaque regrowth study was a 5-cell, randomised, double blind cross-over design, involving 20 healthy human volunteers. The mouthrinse formulations were aqueous 0.05% solutions of cetylpyridinium chloride (CPC), chlorhexidine and triclosan, together with a 0.1% CPC and a minus active control rinse. On Day 1, from a zero plaque baseline, volunteers ceased normal oral hygiene and rinsed 2x daily for 1 min. with 10-ml volumes of the allocated rinses. On Day 5, plaque was scored by index and area. All rinses produced lower mean plaque values compared to control, but unlike the CPC and chlorhexidine rinses, the differences with triclosan did not always reach significance. The CPC and chlorhexidine rinses were always significantly more effective than the triclosan rinse. The greatest plaque inhibition was with 0.1% CPC although rarely significantly greater than the 0.05% CPC and chlorhexidine rinses which were similar in efficacy. The results indicate that further studies on lower concentration chlorhexidine solutions are warranted.
尽管漱口水产品最终配方的可能变化范围极大，但其中使用的活性剂数量相对较少。本研究的目的是比较简单配方中3种抗菌剂相同浓度时对牙菌斑的抑制作用。这项为期4天的牙菌斑再生长研究采用5组随机双盲交叉设计，涉及20名健康人类志愿者。漱口水配方为十六烷基吡啶氯化物（CPC）、洗必泰和三氯生的0.05%水溶液，以及0.1% CPC和一种阴性对照漱口水。在第1天，从牙菌斑零基线开始，志愿者停止正常口腔卫生护理，每天用10毫升分配的漱口水冲洗2次，每次1分钟。在第5天，通过指数和面积对牙菌斑进行评分。与对照相比，所有漱口水的平均牙菌斑值均较低，但与CPC和洗必泰漱口水不同，三氯生漱口水的差异并不总是具有统计学意义。CPC和洗必泰漱口水始终比三氯生漱口水显著更有效。最大的牙菌斑抑制作用是由0.1% CPC产生的，尽管很少显著大于0.05% CPC和洗必泰漱口水，它们的功效相似。结果表明有必要对低浓度洗必泰溶液进行进一步研究。
