Renton-Harper P, Addy M, Moran J, Doherty F M, Newcombe R G
Division of Restorative Dentistry, Dental School, Bristol, UK.
J Periodontol. 1996 May;67(5):486-9. doi: 10.1902/jop.1996.67.5.486.
There are a large number of mouthrinse products available to the general public for use as adjuncts to oral hygiene. Many have not been evaluated and relatively few comparisons of products have been made. This study compared 4 mouthrinse products containing cetylpyridinium chloride (CPC), chlorhexidine, C31G, or triclosan with saline rinse included as a placebo control. Twenty dentate volunteers took part in this 4-day plaque regrowth study which had a single blind, randomized cross-over design balanced for residual effects. On day 1 of each study period, volunteers were rendered plaque free by a professional prophylaxis, suspended normal oral hygiene measures, and rinsed twice daily for 1 minute with 15 mL of the allocated rinse. On day 5, subjects were scored for disclosed plaque by plaque index and plaque area. By both measures the order of decreasing product efficacy was chlorhexidine, CPC and triclosan, C31G, and saline. All the differences in favor of the chlorhexidine product were highly significant as were those in favor of the other rinses compared to saline. It is concluded that the findings of this study reflect the actual chemical benefits of the products divorced from the indeterminate variable of toothbrushing.
有大量漱口水产品可供公众用作口腔卫生的辅助用品。许多产品尚未经过评估，并且对产品进行比较的情况相对较少。本研究将4种含有西吡氯铵（CPC）、氯己定、C31G或三氯生的漱口水产品与作为安慰剂对照的生理盐水冲洗进行了比较。20名有牙的志愿者参与了这项为期4天的牙菌斑再生长研究，该研究采用单盲、随机交叉设计，并对残留效应进行了平衡。在每个研究阶段的第1天，通过专业洁治使志愿者的牙菌斑清除，暂停正常的口腔卫生措施，并每天用15毫升分配的漱口水冲洗两次，每次1分钟。在第5天，通过菌斑指数和菌斑面积对受试者的暴露牙菌斑进行评分。通过这两种测量方法，产品功效从高到低的顺序为氯己定、CPC、三氯生、C31G和生理盐水。与生理盐水相比，所有有利于氯己定产品的差异以及有利于其他漱口水的差异都非常显著。得出的结论是，本研究的结果反映了产品实际的化学益处，而不受刷牙这一不确定变量的影响。
