通过化学发光法定量检测鞘内抗原对单纯疱疹病毒性脑炎进行新型无创快速诊断。
New non-invasive rapid diagnosis of herpes simplex virus encephalitis by quantitative detection of intrathecal antigen with a chemiluminescence assay.
作者信息
Kamei S, Tetsuka T, Takasu T, Shimizu K
机构信息
Department of Neurology, Nihon University School of Medicine, Tokyo, Japan.
出版信息
J Neurol Neurosurg Psychiatry. 1994 Sep;57(9):1112-4. doi: 10.1136/jnnp.57.9.1112.
Abstract
A technique for detecting herpes simplex virus (HSV) antigen in CSF by measuring the antigen-antibody complex-activated complement-stimulated chemiluminescence in normal granulocytes was applied to 17 CSF samples from 10 patients with herpes simplex virus encephalitis (HSVE), and 26 samples from 22 patients with a non-HSVE brain illness. All CSF samples taken from the 5th to the 38th day (including seven from the 5th to the 10th day) of HSVE were positive, whereas those for all non-HSVE samples were negative. This assay required only five hours to yield a result.
摘要
一种通过测量正常粒细胞中抗原 - 抗体复合物激活补体刺激的化学发光来检测脑脊液中单纯疱疹病毒（HSV）抗原的技术，应用于10例单纯疱疹病毒性脑炎（HSVE）患者的17份脑脊液样本，以及22例非HSVE脑部疾病患者的26份样本。从HSVE患者发病第5天至第38天采集的所有脑脊液样本（包括5例患者第5天至第10天的7份样本）均呈阳性，而所有非HSVE样本均为阴性。该检测仅需5小时即可得出结果。
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本文引用的文献
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Rapid non-invasive diagnosis of herpes encephalitis.疱疹性脑炎的快速无创诊断
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