Doe J E, Paddle G M
ZENECA Central Toxicology Laboratory, Macclesfield, Cheshire, United Kingdom.
Regul Toxicol Pharmacol. 1994 Jun;19(3):297-308. doi: 10.1006/rtph.1994.1025.
The International Agency for Research on Cancer (IARC) has reviewed the carcinogenic risk to man of the occupation of spraying or applying insecticides. IARC was unable to conclude that a causal relationship had been established (category 1), but there was some evidence which led them to consider the occupation to be probably carcinogenic (in category 2A). These conclusions have been reviewed by a working group of the International Group of National Associations of Manufacturers of Agrochemical Products (GIFAP) to determine what steps needed to be taken which might improve safety for those working with insecticides. The working group reinforced the view that a causal relationship could not be established. In addition, the usage rate of insecticides has decreased since the time of the studies that IARC considered, their general toxicity has decreased, and the products themselves have been the subject of close regulatory scrutiny. It is considered that these changes are addressing any concerns that may be raised by the IARC report.
国际癌症研究机构（IARC）已对喷洒或施用杀虫剂职业对人类的致癌风险进行了审查。IARC无法得出已确立因果关系的结论（第1类），但有一些证据使他们认为该职业可能具有致癌性（第2A类）。国际农用化学品制造商协会组织（GIFAP）的一个工作组对这些结论进行了审查，以确定需要采取哪些措施来提高使用杀虫剂人员的安全性。该工作组强化了无法确立因果关系的观点。此外，自IARC所考虑的研究时期以来，杀虫剂的使用率有所下降，其总体毒性降低，并且这些产品本身一直受到严格的监管审查。人们认为这些变化正在解决IARC报告可能引发的任何担忧。
