Serup J
Department of Dermatological Research, Leo Pharmaceutical Products, Ballerup, Denmark.
Acta Derm Venereol Suppl (Stockh). 1994;185:5-8.
Bioengineering techniques for examination of the skin, measuring principles and sources of error relative to technique, study design, measuring conditions and variability related to test subjects and preconditioning are reviewed. Principles of validation and standard operating procedures (SOP) are discussed, including guidelines for measurement of transepidermal water loss (TEWL) and laser Doppler cutaneous blood flow. Today typical errors are not related to a measuring device but to the way it is used.
本文综述了用于皮肤检测的生物工程技术、测量原理、与技术相关的误差来源、研究设计、测量条件以及与测试对象和预处理相关的变异性。讨论了验证原则和标准操作程序（SOP），包括经表皮水分流失（TEWL）和激光多普勒皮肤血流测量指南。如今，典型的误差并非与测量设备相关，而是与设备的使用方式有关。
