Schnetz E, Kuss O, Schmitt J, Diepgen T L, Kuhn M, Fartasch M
Department of Dermatology, University of Erlangen-Nürnberg, Erlangen, Germany.
Contact Dermatitis. 1999 May;40(5):243-7. doi: 10.1111/j.1600-0536.1999.tb06057.x.
The volar forearm is the favored location for bioengineering studies. However, transepidermal water loss (TEWL), which is an important indicator of the function of the epidermal barrier, shows regional variations, and for the evaluation of cosmetic formulations, facial skin would be more suitable. In this study, we have compared 10 facial locations with 1 test site on the volar forearm for absolute TEWL values, reproducibility, and correlation. Measurements were performed over 3 consecutive days. The TEWL values of the facial test sites were higher compared to forearm values and did not correlate with the forearm. On the face, there was a good correlation between the values of the right compared to the left side of the face. The sites superior to the nervus supraorbitalis, the medial borders of the musculus masseter, and the center of the chin proved to be locations with relatively stable TEWL values. There was a greater variability at the center of the forehead and at the center of the cheeks. It is recommended that TEWL measurements on facial locations with stable TEWL values are used for the evaluation of cosmetic formulations.
掌侧前臂是生物工程研究的首选部位。然而，经表皮水分流失（TEWL）作为表皮屏障功能的重要指标存在区域差异，对于化妆品配方的评估而言，面部皮肤可能更合适。在本研究中，我们比较了面部的10个部位与掌侧前臂的1个测试部位的绝对TEWL值、重复性及相关性。测量连续进行3天。面部测试部位的TEWL值高于前臂，且与前臂不相关。在面部，右侧与左侧的值之间存在良好的相关性。眶上神经上方、咬肌内侧缘及下巴中心的部位被证明是TEWL值相对稳定的部位。前额中心和脸颊中心的变异性更大。建议使用TEWL值稳定的面部部位测量来评估化妆品配方。
