Rupniak N M, Boyce S, Tye S, Cook G, Iversen S D
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex, UK.
Pharmacol Biochem Behav. 1993 Jan;44(1):153-6. doi: 10.1016/0091-3057(93)90293-3.
Anxiolytic-like and antinociceptive activities of the noncompetitive NMDA receptor antagonist MK-801 (dizocilpine) were compared with sedative and ataxic side effects in primates. Administration of MK-801 (0.1 mg/kg) caused taming in cynomolgus monkeys and increased tail withdrawal latencies in squirrel monkeys; both effects were accompanied by sedation and ataxia. These findings are discussed in relation to the possible therapeutic uses of NMDA antagonists and differences in the behavioural effects of such compounds in primate and rodent species.
将非竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801（地佐环平）的抗焦虑样和抗伤害感受活性与灵长类动物的镇静和共济失调副作用进行了比较。给予MK-801（0.1毫克/千克）可使食蟹猴温顺，并增加松鼠猴的甩尾潜伏期；这两种效应都伴有镇静和共济失调。结合NMDA拮抗剂可能的治疗用途以及此类化合物在灵长类和啮齿类动物行为效应上的差异，对这些发现进行了讨论。
