Tollesson A, Frithz A
Karolinska Institutet, Department of Dermatology, Södersjukhuset, Stockholm, Sweden.
Acta Derm Venereol. 1993 Feb;73(1):18-20. doi: 10.2340/00015555731820.
Thirty-seven patients with clinically diagnosed infantile seborrhoeic dermatitis (ISD) were studied in an attempt to establish the significance of transepidermal water loss (TEWL) and water content in the stratum corneum, in active disease and after recovery. All the patients were treated daily with topically applied borage oil (containing 24% gamma-linolenic acid). With this regimen they were completely free from all skin symptoms within 3-4 weeks. Analyses of essential fatty acids in serum showed aberrations as previously described, with elevated levels of 18:1w9 and 20:2w6. TEWL and water content were recorded at the time of diagnosis and after treatment from the right forearm in skin that was free from symptoms and not treated with borage oil. Twenty-five healthy children in an age-matched group without skin disorders were used as controls. Significant differences in TEWL between patients and controls were found before treatment. After treatment no significant differences were found. There were no significant differences between controls and patients regarding water content in the stratum corneum. Gamma-linolenic acid is suggested to be of importance in maintaining normal TEWL and also in promoting recovery in patients suffering from ISD.
对37例临床诊断为婴儿脂溢性皮炎（ISD）的患者进行了研究，旨在确定经表皮水分流失（TEWL）和角质层含水量在疾病活动期及恢复后的意义。所有患者每日外用琉璃苣油（含24%γ-亚麻酸）进行治疗。采用该治疗方案，患者在3 - 4周内所有皮肤症状完全消失。血清中必需脂肪酸分析显示出如先前所述的异常，18:1w9和20:2w6水平升高。在诊断时及治疗后，于右前臂无症状且未用琉璃苣油治疗的皮肤上记录TEWL和含水量。选取25名年龄匹配、无皮肤疾病的健康儿童作为对照。治疗前发现患者与对照之间TEWL存在显著差异。治疗后未发现显著差异。对照与患者在角质层含水量方面无显著差异。γ-亚麻酸被认为在维持正常TEWL以及促进ISD患者康复方面具有重要作用。
