Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Thailand.
Biomed Res Int. 2019 Jul 8;2019:5128376. doi: 10.1155/2019/5128376. eCollection 2019.
Scalp seborrheic dermatitis (SD) is a common and chronic inflammatory skin disease which tends to recur over time. By measuring biophysical properties of the stratum corneum, many studies report abnormal biophysical profiles and their association in various dermatologic diseases. The aim of the study is to analyze the biophysical properties and skin barrier defects of scalp SD compared to healthy controls.
This study is a cross-sectional study assessing the correlation of various biophysical and physiological profiles in scalp SD. Forty-two Thai participants with scalp SD were enrolled in the study and 40 healthy participants were also enrolled as the control group. Both SD and control group were subjected to a one-time biophysical and physiological properties' measurement of transepidermal water loss (TEWL), stratum corneum hydration (SCH), skin surface pH, skin surface lipid, and skin roughness.
The mean TEWL of lesional skin of SD cases were significantly higher than those of control group (<0.05). Relating to high mean TEWL, the mean SCH was found to be significantly lower in SD cases (<0.05). Skin surface lipid was also found to be significantly higher in SD group (<0.05). However, there were no differences in skin surface pH (=0.104) and roughness (=0.308) between the two groups. Pairwise comparison of each subgroup found that moderate and severe SD demonstrated significantly higher mean skin surface lipid than that of control group (<0.05).
Scalp SD may be associated with seborrhea in Thai population. Monitoring of SCH, TEWL, and skin surface lipid could be helpful in assessing severity and evaluating the treatment outcome in patients with scalp SD.
头皮脂溢性皮炎（SD）是一种常见的慢性炎症性皮肤病，随着时间的推移往往会复发。通过测量角质层的生物物理特性，许多研究报告了各种皮肤病中异常的生物物理特征及其相关性。本研究旨在分析头皮 SD 与健康对照组之间的生物物理特性和皮肤屏障缺陷。
这是一项横断面研究，评估了头皮 SD 中各种生物物理和生理特征的相关性。本研究纳入了 42 名泰国头皮 SD 患者，并纳入了 40 名健康参与者作为对照组。SD 组和对照组均进行了一次瞬态表皮水分流失（TEWL）、角质层水分（SCH）、皮肤表面 pH 值、皮肤表面脂质和皮肤粗糙度的生物物理和生理特性测量。
SD 病例皮损处的平均 TEWL 明显高于对照组（<0.05）。与高平均 TEWL 相关，SD 病例的平均 SCH 明显较低（<0.05）。SD 组的皮肤表面脂质也明显较高（<0.05）。然而，两组之间的皮肤表面 pH 值（=0.104）和粗糙度（=0.308）没有差异。每个亚组的两两比较发现，中度和重度 SD 的平均皮肤表面脂质明显高于对照组（<0.05）。
头皮 SD 可能与泰国人群中的皮脂溢有关。监测 SCH、TEWL 和皮肤表面脂质有助于评估头皮 SD 患者的严重程度和治疗效果。
