Tollesson A, Frithz A, Stenlund K
Karolinska Institute, Department of Dermatology, Stockholm, Sweden.
Pediatr Dermatol. 1997 Nov-Dec;14(6):423-5. doi: 10.1111/j.1525-1470.1997.tb00680.x.
Malassezia furfur is important in the pathogenesis of a number of dermatologic diseases including seborrheic dermatitis in adults. It has also recently been suggested that M. furfur might be the etiologic agent in infantile seborrheic dermatitis (ISD). We studied the presence of M. furfur in 21 children with the clinical diagnosis of infantile seborrheic dermatitis. Laboratory analyses showed aberrant patterns of essential fatty acids (EFA) in serum characterized by elevated levels of 18:1w9 and 20:2w6. Samples for M. furfur were taken from the foreheads and chests of children with infantile seborrheic dermatitis at the time of diagnosis, directly after treatment to complete healing, and after 1 year with no signs of infantile seborrheic dermatitis. All the patients were treated topically with borage oil containing 25% gammalinolenic acid (GLA). No reduced growth of M. furfur was seen on contact plates prepared with borage oil. The growth of M. furfur seems not to be related to the clinical symptoms in ISD.
糠秕马拉色菌在包括成人脂溢性皮炎在内的多种皮肤病发病机制中起重要作用。最近也有人提出，糠秕马拉色菌可能是婴儿脂溢性皮炎（ISD）的病原体。我们研究了21例临床诊断为婴儿脂溢性皮炎的儿童中糠秕马拉色菌的存在情况。实验室分析显示血清中必需脂肪酸（EFA）模式异常，其特征为18:1w9和20:2w6水平升高。在诊断时、治疗至完全愈合后以及1年后无婴儿脂溢性皮炎迹象时，从患有婴儿脂溢性皮炎的儿童的前额和胸部采集糠秕马拉色菌样本。所有患者均外用含25%γ-亚麻酸（GLA）的琉璃苣油进行治疗。在用琉璃苣油制备的接触平板上未观察到糠秕马拉色菌生长减少。糠秕马拉色菌的生长似乎与婴儿脂溢性皮炎的临床症状无关。
